住院精神分裂症患者脂代谢异常发生率及其相关因素调查  

Investigation and analysis of the incidence of abnormal lipid metabolism and its related factors in hospitalized schizophrenia patients

作　　者：班春霞[1] 李清伟[2] 李慧娟[1] 陈翔春[1] 孟美玲 张袁杰 于伟霞 高存友 BAN Chunxia;LI Qingwei;LI Huijuan(Mental Health Center of Jlading District in Shanghai,Shanghai 201806,China)

机构地区：[1]上海市嘉定区精神卫生中心,上海201806 [2]同济大学附属同济医院

出　　处：《国际精神病学杂志》2021年第4期611-614,619,共5页Journal Of International Psychiatry

基　　金：上海市嘉定区农业和社会事业科研项目(编号:JDKW-2019-W06);嘉定区精神卫生重点专科建设项目(编号:JDYXZDZK-3)。

摘　　要：目的对住院精神分裂症患者脂代谢异常发生率及其相关因素进行调查。方法采用自制的调查表对235例住院精神分裂症患者进行调查,分别收集患者的性别、年龄、受教育年限、性格、病程、住院时间、既往病史(高血压、糖尿病)、服用抗精神病药物等相关资料,同时检测体质量、身高、空腹血糖、甘油三酯、总胆固醇、高密度脂蛋白及低密度脂蛋白等相关指标。结果 235例住院精神分裂症患者中,存有脂代谢异常158例,发生率为67.2%。外向、超重、高血压及未服用阿立哌唑患者更易发生脂代谢异常(P<0.05)。外向患者总胆固醇及甘油三酯均明显高于内向患者(P<0.05)。超重患者甘油三酯明显高于非超重患者(P<0.01)。高血压住院精神分裂症患者甘油三酯明显高于非高血压患者(P<0.05)。Logistic回归分析显示,外向、超重是脂代谢异常发生的高危因素,服用阿立哌唑是脂代谢异常发生的保护性因素。结论住院精神分裂症患者脂代谢异常发生率较高,外向、超重的患者较易发生脂代谢异常,而服用阿立哌唑可降低脂代谢异常发生的风险。Objective To investigate the incidence of abnormal lipid metabolism of hospitalized schizophrenia inpatients and relative factors. Methods A self-made questionnaire was used to investigate the 235 hospitalized schizophrenia inpatients. Gender,age,educated years,course of disease,hospital stays,past medical history(hypertension,diabetes),and use of antipsychotic drugs were collected. Meanwhile,body mass,height,blood glucose,triglycerides,total cholesterol,high-density lipoprotein and low-density lipoprotein were measured. Results Among 235 hospitalized schizophrenia inpatients,158(67.2%)cases of which were complicated with abnormal lipid metabolism. Extraverted,overweight,hypertensive and non-aripiprazole patients were more likely to have abnormal lipid metabolism(P< 0.05). Total cholesterol and triglyceride in extraverted patients were significantly higher than that in introverted patients(P< 0.05). Triglyceride in overweight patients was significantly higher than that in non-overweight patients(P< 0.01). Triglycerides were significantly higher in hypertensive inpatients with schizophrenia than in non-hypertensive patients(P< 0.05). Logistic regression analysis showed that extraversion and overweight were high risk factors for abnormal lipid metabolism,while aripiprazole was a protective factor for abnormal lipid metabolism. Conclusions The incidence of abnormal lipid metabolism was higher in hospitalized schizophrenics. Extroverted,overweight patients are more prone to abnormal lipid metabolism,and aripiprazole can reduce the risk of lipid metabolism abnormalities.

关 键 词：精神分裂症 脂代谢异常 相关因素 

分 类 号：R749.3[医药卫生—神经病学与精神病学]