Spadin及其类似物治疗脑卒中后抑郁的研究进展  

Recent advance in Spadin and its analogs in treatment of post-stroke depression

作　　者：王秀丽 魏巍[2] 房翠 张梦瑶 史福平[1] Wang Xiuli;Wei Wei;Fang Cui;Zhang Mengyao;Shi Fuping(Department of Neurology,Affiliated Hospital of Hebei University,Baoding 071000,China;Department of Radiology,Hebei Province Veterans Hospital,Baoding 071000,China)

机构地区：[1]河北大学附属医院神经内科,保定071000 [2]河北省荣军医院放射科,保定071000

出　　处：《中华神经医学杂志》2021年第9期956-959,共4页Chinese Journal of Neuromedicine

基　　金：河北省重点研发科技项目(18277795D)。

摘　　要：脑卒中后抑郁(PSD)是脑卒中后常见的精神疾病之一,预防和治疗工作均存在一定难度。双孔钾离子通道TREK-1是脑卒中和PSD发病机制中的一个重要靶点,与神经保护以及情绪的调控密切相关,抑制TREK-1通道的活性能够发挥明显抗抑郁效果。近年来研究发现TREK-1通道阻滞剂Spadin及其类似物对于治疗缺血性脑卒中以及PSD有较好疗效。本文现围绕Spadin及其类似物的发现、作用及其对PSD的治疗价值等内容综述如下。Post-stroke depression(PSD)is one kind of the common mental diseases after stroke,and the prevention and treatment of PSD are very difficult.TREK-1,a two-pore domain potassium channel,is an important target in the pathogenesis of stroke and PSD,and it is closely related to neuroprotection and emotion regulation;inhibition of activity of TREK-1 channel can exert significant antidepressant effect.In recent years,TREK-1 channel blocker Spadin and Spadin analogs are discovered,and they have a relatively significant effect on ischemic stroke and PSD.In this paper,the research progress on the discovery,efficacy and therapeutic value of Spadin and Spadin analogs in PSD are summarized as follows.

关 键 词：脑卒中后抑郁 Spadin Spadin类似物 TREK-1 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R749.4[医药卫生—临床医学]