基质交感分子1在消化系统疾病中的研究进展  

Stromal interaction molecule 1 in digestive diseases:research progress

作　　者：唐健 李兆申[1] 刘枫 TANG Jian;LI Zhao-shen;LIU Feng(Department of Gastroenterology,Changhai Hospital,Naval Medical University(Second Military Medical University),Shanghai 200433,China;Digestive Endoscopy Center,Shanghai Tenth People’s Hospital,Tongji University School of Medicine,Shanghai 200072,China)

机构地区：[1]海军军医大学(第二军医大学)长海医院消化内科,上海200433 [2]同济大学医学院上海第十人民医院消化内镜中心,上海200072

出　　处：《第二军医大学学报》2021年第9期1032-1036,共5页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金(81670604)。

摘　　要：基质交感分子1是新近发现的位于内质网膜上的Ca^(2+)感受器,是一种与细胞Ca^(2+)内流有关的跨膜蛋白。它作为钙库操纵性Ca^(2+)内流过程中的重要调控蛋白,在非兴奋细胞Ca^(2+)稳态平衡中起关键作用。目前已有国内外研究证实基质交感分子1在肿瘤、炎症、免疫等疾病的发生、发展中具有重要作用。本文就基质交感分子1在消化系统疾病中的最新进展进行总结,简述其潜在的基础研究与临床价值。Stromal interaction molecule 1(STIM1)is a recently discovered Ca^(2+)receptor located on the membrane of endoplasmic reticulum,and it is a transmembrane protein related to cellular Ca^(2+)influx.As an important regulatory protein in the process of store-operated Ca^(2+)entry,STIM1 plays an essential role in Ca^(2+)homeostasis of non-excited cell.To date,domestic and foreign studies have confirmed that STIM1 plays an important role in the development and progression of various diseases such as tumor,inflammation and immunity.This article summarizes the latest research progress of STIM1 in digestive diseases,and briefly describes its potential basic research and clinical value.

关 键 词：基质交感分子1 钙库操纵性钙内流 消化系统疾病 肿瘤 炎症 

分 类 号：R57[医药卫生—消化系统] R735[医药卫生—内科学]