高压氧联合银杏叶提取物对突发性耳聋患者血清学指标及听力水平的影响  

Effect of hyperbaric oxygen combined with Ginkgo Biloba Extract on serum indexes and hearing level of patients with sudden deafness

作　　者：黄振河[1] 王心涛[1] 游龙贵[1] 张克辉[1] 王富华[1] HUANG Zhen-he;WANG Xin-tao;YOU Long-gui;ZHANG Ke-hui;WANG Fu-hua(Department of Otorhinolaryngology,Head and Neck Surgery,People′s Hospital of Ganzhou City,Jiangxi Province,Ganzhou 341000,China)

机构地区：[1]江西省赣州市人民医院耳鼻咽喉头颈外科,江西赣州341000

出　　处：《中国当代医药》2021年第27期10-13,共4页China Modern Medicine

基　　金：江西省卫生健康委员会科技计划项目(202140746)。

摘　　要：目的探讨高压氧联合银杏叶提取物治疗突发性耳聋(SHL)的临床效果和对听力水平的影响。方法选取2018年10月至2020年10月赣州市人民医院收治的88例SHL患者作为研究对象,按照随机数字表法将其分为对照组与观察组,每组各44例。两组患者均行常规治疗,对照组患者加用银杏叶提取物治疗,观察组患者在对照组的基础上予以高压氧治疗。比较两组患者的血清学指标、血液流变学指标、听力水平和不良反应发生情况。结果治疗前,两组患者的血清学指标比较,差异无统计学意义(P>0.05);治疗后,两组患者的一氧化氮(NO)、超氧化物岐化酶(SOD)水平高于治疗前,C反应蛋白(CRP)、过氧化脂(LPO)水平低于治疗前,差异有统计学意义(P<0.05);治疗后,观察组患者的NO、SOD水平高于对照组,CRP、LPO水平低于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者的血液流变学指标比较,差异无统计学意义(P>0.05);治疗后,两组患者的血浆黏度(PV)、全血高切黏度(HSV)、低切黏度(LSV)低于治疗前,差异有统计学意义(P<0.05);治疗后,观察组患者的PV、HSV、LSV低于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者的听力水平比较,差异无统计学意义(P>0.05);治疗后,两组患者的高频区、低频区听阈低于治疗前,差异有统计学意义(P<0.05);治疗后,观察组患者的高频区、低频区听阈低于对照组,差异有统计学意义(P<0.05)。两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论高压氧联合银杏叶提取物治疗可改善SHL患者的血清学指标,纠正血液流变学异常,促进听力水平恢复,安全可靠。Objective To investigate the clinical effect of hyperbaric oxygen combined with Ginkgo Biloba Extract in the treatment of sudden hearing loss(SHL)and its influence on hearing level.Methods A total of 88 SHL patients admitted to eople′s Hospital of Ganzhou City from October 2018 to October 2020 were selected as the research objects and divided into the control group and the observation group according to the random number table method,with 44 cases in each group.Both groups received conventional treatment,the control group was treated with Ginkgo Biloba Extract,and the observation group was treated with hyperbaric oxygen based on the basis of the control group.The serum indexes,hemorheology indexes,hearing level and adverse reactions were compared between the two groups.Results There were no statistically significant differences in serum indexes between the two groups before treatment(P>0.05).After treatment,the levels of nitric oxide(NO)and superoxide dismutase(SOD)in the two groups were higher than those before treatment,and the levels of C-reactive protein(CRP)and lipid peroxide(LPO)were lower than those before treatment,the differences were statistically significant(P<0.05).After treatment,the levels of NO and SOD in the observation group were higher than those in the control group,the levels of CRP and LPO were lower than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there was no statistically significant difference in hemorheology between the two groups(P>0.05).After treatment,plasma viscosity(PV),whole blood high shear viscosity(HSV)and low shear viscosity(LSV)of the two groups were lower than those before treatment,and the differences were statistically significant(P<0.05).After treatment,PV,HSV and LSV in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There were no statistically significant differences in hearing levels between the two groups before treatment(P>0.05).Afte

关 键 词：突发性耳聋 高压氧 银杏叶提取物 血清学指标 听力水平 不良反应 

分 类 号：R764.437[医药卫生—耳鼻咽喉科]