微生物-肠-脑轴与酒精诱导脑损伤的研究进展  

Research progress of the microbiota-gut-brain axis and alcohol-induced brain injury

作　　者：厉颖 李灿委 范孟然 尹爱武 刘卫红 高鹏飞 LI Ying;LI Canwei;FAN Mengran;YIN Aiwu;LIU Weihong;GAO Pengfei(College of Pharmacy,Dali University,Dali 671000,China;College of Public Health,Dali University,Dali 671000;Xiangtan Medicine and Health Vocational College,Xiangtan 411104;Department of Agriculture and biological Science,Dali University,Dali 671000;Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D,Dali University,Dali 671000)

机构地区：[1]大理大学药学院,云南大理671000 [2]大理大学公共卫生学院,云南大理671000 [3]湘潭医卫职业技术学院,湖南湘潭411104 [4]大理大学农学与生物科学学院,云南大理671000 [5]云南省昆虫生物医药研发重点实验室,云南大理671000

出　　处：《中国比较医学杂志》2021年第9期124-129,共6页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基因项目(81260676,81960712);中国国家留学基金(201708535007);云南省教育厅科学研究基金重点项目(2013Z154);云南省2019年中药饮片产业发展专项资金(2019-YG-067);本科高校(部分)基础研究联合专项项目(2018FH001-097)。

摘　　要：酒精可诱发大脑功能障碍,肠道微生物可通过肠-脑轴介导酒精对脑损伤的影响。目前,酒精通过微生物-肠-脑轴介导脑损伤的机制研究主要包括炎症、内毒素、色氨酸代谢等。探索酒精与微生物-肠-脑轴间的相互作用,有助于深入了解酒精对脑部的影响,为探索酒精诱导脑损伤的发病机制提供新思路。Alcohol can induce brain dysfunction,and gut microbiota can mediate the effects of alcohol on brain injury through the gut-brain axis. At present,the mechanisms of alcohol-mediated brain injury through the microbiota-gutbrain axis mainly include inflammation,endotoxins and tryptophan metabolism. Exploring the interactions between alcohol and the microbiota-gut-brain axis will be helpful for understanding the effects of alcohol on the brain,and will provide a new way to explore the pathogenesis of alcohol-induced brain injury.

关 键 词：酒精 脑损伤 微生物-肠-脑轴 肠道微生物 

分 类 号：R-33[医药卫生]