临床病理特征和超声征象对三阴性乳腺癌患者生存期的评估价值  

Prognostic value of clinic-pathological characteristics and ultrasound features for assessment of triple negative breast cancer

作　　者：欧阳丽珠 龚海燕 杨雅婷 王平 OUYANG Lizhu;GONG Haiyan;YANG Yating;WANG Ping(Department of Ultrasound,The Third Affiliated Hospital Southern Medical University,Guangzhou 510630,China;Department of Ultrasound,Shunde Hospital Southern Medical University,Foshan 528308,China)

机构地区：[1]南方医科大学第三附属医院超声科,广东广州510630 [2]南方医科大学顺德医院超声科,广东佛山528308

出　　处：《分子影像学杂志》2021年第5期792-798,共7页Journal of Molecular Imaging

基　　金：广东省医学科学技术研究基金项目(A2020089)。

摘　　要：目的探讨三阴性乳腺癌(TNBC)患者临床病理特征以及超声征象在患者预后评估中的价值。方法回顾性收集2012年1月~2017年12月间接受治疗的TNBC病患者的临床病理资料、超声特征、无复发生存期和总生存期;采用Cox比例风险回归及Kaplan-Meier生存分析法评价临床病理特征及超声征象对TNBC患者预后评估价值。结果共纳入78例TNBC患者,中位随访时间为40月,其中18例(23.1%)患者发生局部复发或转移,18例(23.1%)患者死亡。单因素分析显示绝经前期/围绝经期、病灶最大径>2 cm、腋窝淋巴结转移、Ki-67>30%、纤维腺体型乳腺、非平行生长及脉管侵犯与患者预后不良有关(P<0.05),多因素分析显示仅非平行生长及脉管浸润为无复发生存期及总生存期独立危险因素(P<0.05)。结论脉管侵犯及肿块非平行生长与TNBC患者预后不良相关。Objective To investigate the value of clinic-pathological characteristics and ultrasound features in predicting the prognosis of triple negative breast cancer(TNBC).Methods Patients with TNBC treated between January 2012 and December 2017 were retrospectively included.Patients'clinic-pathological,ultrasound features,recurrence-free survival,and overall survival were collected.Cox regression and Kaplan-Meier analysis were used to determine the prognostic factors of TNBC.Results A total of 78 TNBC patients were included with a median follow-up of 40 months.Eighteen patients(23.1%)experienced recurrence and 18 patients(23.1%)occurred deaths.Univariate Cox analysis showed that pre/peri-menopausal patients,maximum tumor diameter>2 cm,positive axillary lymph node,Ki-67 expression>30%,fibroglandua breast,non-parallel oriented,and lymphatic vascular invasion are associated with poorer prognosis(P<0.05).Multivariable Cox analysis found that only non-parallel oriented and lymphatic vascular invasion were two independent predictors of recurrence-free survival and overall survival(P<0.05).Conclusion Peripheral lymphatic vascular invasion and tumor non-parallel growth are associated with poor prognosis in TNBC patients.

关 键 词：三阴性乳腺癌 预后 超声 非平行生长 脉管侵犯 

分 类 号：R737.9[医药卫生—肿瘤] R445.1[医药卫生—临床医学]