结肠镜检查联合血清CEA、TuM2-PK检测对结肠癌的诊断价值  

The value of colonoscopy combined with serum CEA and TuM2-PK in the diagnosis of colon cancer

作　　者：王计[1] 吴小微[1] 晏妮 WANG Ji;WU Xiaowei;YAN Ni(Department of Gastroenterology,Hanyang Hospital Affiliated to Wuhan University of Science and Technology,Wuhan,Hubei,China,430050)

机构地区：[1]武汉科技大学附属汉阳医院消化内科,湖北武汉430050

出　　处：《分子诊断与治疗杂志》2021年第9期1394-1397,共4页Journal of Molecular Diagnostics and Therapy

基　　金：国家卫生计生委医药卫生科技发展研究中心课题(W2015JZC30)。

摘　　要：目的探讨结肠镜检查联合CEA、TuM2-PK对结肠癌的诊断价值。方法选取2019年1月至2020年12月武汉科技大学附属汉阳医院150例疑似结肠癌患者,根据术后病理检查结果分为结肠癌组与非结肠癌组,分析结肠镜下检视结果、血清CEA、TuM2-PK水平,并评价结肠镜检查、血清CEA、TuM2-PK水平对结肠癌的诊断价值。结果 150例疑似结肠癌患者恶性比例66.67%;结肠癌组结肠镜下检出率、血清CEA、TuM2-PK水平均高于非结肠癌组,且不同病理分期、分化程度及是否淋巴结转移与结肠癌患者结肠镜下检出率、血清CEA、TuM2-PK水平相比,差异有统计学意义(P<0.05);结肠镜下检查结肠癌患者血清CEA、TuM2-PK水平均高于非结肠癌患者(P<0.05);ROC曲线显示,结肠镜下检查结果、血清CEA、TuM2-PK水平联合诊断结肠癌AUC最大,为0.961。结论结肠镜下检查、血清CEA、TuM2-PK均可用于疑似病例的结肠癌诊断及病情、病理评价,联合使用可提高结肠癌诊断价值,实现早发现早治疗。Objective To explore the diagnostic value of colonoscopy combined with CEA and TuM2-PK for colon cancer.Methods A total of 150 patients with suspected colon cancer in Hanyang Hospital Affiliated to Wuhan University of Science and Technology from January 2019 to December 2020 were selected and divided into the colon cancer group and the non-colon cancer group according to the results of postoperative pathological examination.The results of colonoscopy examination,serum CEA,TuM2-PK were analyzed to evaluate the value of colonoscopy,serum CEA and TuM2-PK levels in the diagnosis of colon cancer.Results The malignant ratio of 150 patients with suspected colon cancer was 66.67%.The colonic cancer group’ colonoscopy detection rate,serum CEA,and TuM2-PK levels were higher than those in the non-colon cancer group,and the different pathological stages,degree of differentiation,and lymph node metastasis were compared with colon cancer patients’ colonoscopy detection rate,serum CEA and TuM2-PK levels,the difference was statistically significant(P<0.05).The serum CEA and TuM2-PK levels of colon cancer patients under colonoscopy were higher than those of non-colon cancer Patients(P<0.05).The ROC curve showed that the combined diagnosis of colon cancer with colonoscopy,serum CEA,and TuM2-PK levels had the highest AUC,which was 0.961.Conclusion Colonoscopy,serum CEA,and TuM2-PK can be used for colon cancer diagnosis and disease condition and pathological evaluation.The combination of various indicators can improve the diagnostic value of colon cancer and realize early detection and early treatment.

关 键 词：结肠镜 癌胚抗原 肿瘤M2型丙酮酸激酶 结肠癌 

分 类 号：R735.35[医药卫生—肿瘤]