CXCR4、RGS4及RAGE在小儿肾母细胞瘤中的表达及临床意义  

The expression and clinical significance of CXCR4,RGS4 and RAGE in patients with pediatric nephroblastoma

作　　者：胡传兵[1] 韩暖 于宝华[1] 田俊严[1] 孙劲松[1] HU Chuanbing;HAN Nuan;YU Baohua;TIAN Junyan;SUN Jinsong(Department of Pediatric Surgery,Affiliated Hospital of Jining Medical College,Jining,Shandong,China,272000)

机构地区：[1]济宁医学院附属医院小儿外科,山东济宁272000

出　　处：《分子诊断与治疗杂志》2021年第9期1511-1514,1519,共5页Journal of Molecular Diagnostics and Therapy

基　　金：山东省自然科学基金(ZR2017YL013)。

摘　　要：目的分析选择趋化因子受体(CXCR4)、蛋白信号调节因子4(RGS4)、晚期糖基化终末产物受体(RAGE)在小儿肾母细胞瘤中的表达及临床意义。方法选取2015年6月至2020年6月本院收治的98例小儿肾母细胞瘤患者,手术留取肾母细胞瘤组织纳入研究组,并选取距离肿瘤边缘>5 cm的正常肾组织纳入对照组(经病理筛查无癌细胞后最终纳入73例)。比较两组CXCR4、RGS4及RAGE表达水平,分析影响肾母细胞瘤患者预后死亡的独立危险因素。结果对照组CXCR4、RAGE高表达率低于研究组,RGS4高表达率高于研究组,差异均有统计学意义(P<0.05)。临床分期Ⅲ~Ⅳ期、预后不良组织结构(UH)、有淋巴结转移者CXCR4、RAGE高表达率高于临床分期Ⅰ~Ⅱ期、预后良好组织结构(FH)及无淋巴结转移者,差异均有统计学意义(P<0.05)。FH者RGS4高表达率高于UH者,差异有统计学意义(P<0.05)。临床分期Ⅲ~Ⅳ期、预后不良组织结构、有淋巴结转移、CXCR4、RAGE高表达及RGS4低表达是影响肾母细胞瘤患者预后死亡的危险因素(P<0.05)。结论 CXCR4、RGS4及RAGE在小儿肾母细胞瘤组织中表达异常,并与肾母细胞瘤发生、发展有关,临床上可通过检测三者表达情况对患者病情进展及预后进行评估。Objective To analyze the expression and clinical significance of CXCR4,RGS4 and RAGE in patients with pediatric nephroblastoma.Methods 98 patients with pediatric nephroblastoma who were admitted to this hospital from June 2015 to June 2020 were selected.Wilms tumor tissue collected from surgery was included in the study group,and normal kidney tissue>5 cm away from the edge of the tumor were selected as the control group(73 cases without cancer cells were finally included after pathological screening).The expression levels of CXCR4,RGS4 and RAGE in different groups were compared,and the independent risk factors affecting the prognostic death of patients with Wilms tumor were analyzed.Results The high expression rates of CXCR4 and RAGE in the control group were significantly lower than those in the study group,and the high expression rate of RGS4 was significantly higher than that in the study group,and the differences were all statistically significant(P<0.05).The high expression rates of CXCR4 and RAGE in patients with clinical stage Ⅲ to Ⅳ, poor prognosis tissue structure(UH),and lymph node metastasis were significantly higher than those in patients with clinical stage Ⅰ to Ⅱ, good prognosis tissue structure(FH) and no lymph node metastasis(P<0.05).The high expression rate of RGS4 in FH patients was higher than that in UH patients(P<0.05).The clinical stage Ⅲ~Ⅳ, UH,lymph node metastasis,high expressions of CXCR4 and RAGE,and low expression of RGS4 were risk factors affecting the prognostic death of patients with pediatric nephroblastoma(P<0.05).Conclusion CXCR4,RGS4 and RAGE are abnormally expressed in pediatric nephroblastoma tissues,and are related to the occurrence and development of nephroblastoma.Clinically,the progress and prognosis of patients can be evaluated by detecting the expression of the threeindicators.

关 键 词：CXCR4 RGS4 小儿肾母细胞瘤 RAGE 

分 类 号：R737.11[医药卫生—肿瘤]