乳腺囊内乳头状癌临床病理及预后分析  

The clinicopathological and prognostic analysis of intracystic papillary carcinoma

作　　者：罗华[1] 何俊玲[1] 杨欧欧[1] 蓝天[1] 苏昆仑[1] 杨慧芬[1] 詹晨妮 何佳炜 徐海滨[1] 胡祖健[1] Luo hua

机构地区：[1]杭州市中医院,310007

出　　处：《浙江临床医学》2021年第9期1248-1251,共4页Zhejiang Clinical Medical Journal

基　　金：浙江省基础公益研究计划项目(LCD20HI90002)。

摘　　要：目的探讨乳腺囊内乳头状癌(IPC)的临床生物学特性及预后。方法选取2007年至2017年经手术病理确诊的W例IPC患者(IPC组),随机按1:3比例选择同期浸润性导管癌45例患者(IDC组),比较两组患者的临床病理指标,包括年龄、性别、肿瘤大小、超声表现、钥靶表现、淋巴结转移状况、分子分型、无复发生存等。结果IPC组与IDC组在发病年龄、性别、超声表现、腋窝淋巴结转移均差异有统计学意义(P<0.05),在肿瘤大小、钳靶表现、分子分型等方面差异无统计学意义(P>0.05)o所有患者中位随访63个月(20〜96个月),IPC组和IDC组无复发生存率(RFS)分别为93.3%和82.2%,差异无统计学意义(P>0.05)□结论与IDC相比,IPC好发于老年患者,特别是绝经后女性,男性发病较IDC占比更高,超声表现为囊实混合的界清肿块更多见,淋巴结转移更少见;IPC总预后好,对于IPC合并浸润性癌,建议行前哨淋巴结活检评估腋窝。Objective Discuss the clinical,biological characteristics and prognosis of intracystic papillary carcinoma.Methods We retrospectively reviewed the clinicopathological findings and treatment outcomes of 15 cases of IPC and 45 cases of IDC who were selected between 2007 and 2017 at the Department of Breast Surgery of Hangzhou Hospital of Traditional Chinese Medicine,and the IDC group were through the random number table method 1/3 at the same time.Clinicopathological features including age,gender,tumor size,radiographic characteristics,lymph node metastasis,molecular typing,and recurrence—free survival were collected to compare differences.Results There were significant differences in age,gender,ultrasound characteristics,lymph node metastasis in IPC and IDC group(P<0.05),and there was no statistical difference(P>0.05)in tumor size,mammographic findings,and molecular typing.For all patients with a median follow-up of 63 months,Kaplan—Meier curves showed no significant difference in recurrence-free survival(RFS)between the IPC and IDC group(93.3%and 82.2%,respectively,P=0.51).Conclusion Compared with IDC,IPC has a higher male patient rate,more complex cystic findings with well-defined margin on ultrasound examination,and lower lymph node metastasis rate.IPC occurs more commonly in elderly patients,especially in postmenopausal women.The overall prognosis and long-term survival are excellent,and we propose that evaluation of the SLN should be routinely indicated for patients who have an IPC associated with invasive cancer.

关 键 词：乳腺囊内乳头状癌 临床病理 预后 

分 类 号：R73[医药卫生—肿瘤]