免疫调节分子Rho GTP酶活化蛋白11A(ARHGAP11A)在肺腺癌高表达且与预后差正相关  

Rho GTPase-activating protein 11A (ARHGAP11A) is up-regulated in lung adenocarcinoma and positively associated with poor prognosis

作　　者：闫柄文 韩明伟 刘蓉蓉 YAN Bingwen;HAN Mingwei;LIU Rongrong(Department of Plastic Surgery,Xijing Hospital,School of Basic Medicine,Air Force Medical University,Xi’an 710032,China;Cadet Brigade,School of Basic Medicine,School of Basic Medicine,Air Force Medical University,Xi’an 710032,China;Department of Microbiology and Pathogenic Biology,School of Basic Medicine,Air Force Medical University,Xi’an 710032,China)

机构地区：[1]空军军医大学西京医院整形外科,陕西西安710032 [2]空军军医大学基础医学院学员队,陕西西安710032 [3]空军军医大学基础医学院微生物与病原生物学教研室,陕西西安710032

出　　处：《细胞与分子免疫学杂志》2021年第7期596-601,共6页Chinese Journal of Cellular and Molecular Immunology

基　　金：国家自然科学基金(81602494);陕西省自然科学研究计划(2019JM-437)。

摘　　要：目的研究Rho GTP酶活化蛋白11A(ARHGAP11A)在肺腺癌中的表达及临床意义。方法通过检索Oncomine等多个在线数据库,获取和分析ARHGAP11A在肺腺癌和正常组织中的表达,并对肺癌患者相关的临床病理参数和生存数据进行生物信息学分析,采用PrognoScan预后分析数据库分析ARHGAP11A基因表达和肺腺癌预后的关系,利用检索相互作用基因/蛋白质的搜索工具(STRING)数据库构建ARHGAP11A及其功能相关基因网络。结果与正常组织相比,ARHGAP11A在肺腺癌的癌组织高表达,且临床分期越晚癌组织分化越差,ARHGAP11A表达越高,临床预后也越差。结论ARHGAP11A在肺腺癌组织高表达且与肺腺癌预后差相关。Objective To clarify the expression and clinical significance of ARHGAP11A in lung adenocarcinoma. Methods The expression of ARHGAP11A in lung adenocarcinoma and normal tissue was obtained and analyzed by searching online databases such as Oncomine, and bioinformatic analysis was carried out on the relevant clinicopathological parameters and survival data of lung cancer patients. PrognoScan prognostic analysis database was used to analyze the relationship between ARHGAP11A gene expression and prognosis of lung adenocarcinoma. STRING database was used to construct ARHGAP11A and its function-related gene network. Results Compared with normal tissue, ARHGAP11A was highly expressed in lung adenocarcinoma, and the later the clinical stage and the worse the differentiation, the higher the expression of ARHGAP11A and the worse the prognosis. Conclusion ARHGAP11A is highly expressed in lung adenocarcinoma and is related to poor prognosis of lung adenocarcinoma.

关 键 词：Rho GTP酶活化蛋白11A(ARHGAP11A) 肺腺癌 预后 

分 类 号：Q811.4[生物学—生物工程] R734.2[医药卫生—肿瘤]