微生物-肠-脑轴研究进展  

Research progress of microbe gut brain axis

作　　者：孙瑾 徐睿 张云峰[1] 田昕[1] Sun Jin;Xu Rui;Zhang Yunfeng;Tian Xin(Pediatric Diagnosis and Treatment Center,The Second Hospital of Jilin University,Changchun 130000,China)

机构地区：[1]吉林大学第二医院儿科诊疗中心,长春130000

出　　处：《中国综合临床》2021年第5期466-470,共5页Clinical Medicine of China

基　　金：吉林省财政厅卫生专项项目 (XEKYZ003)。

摘　　要：肠道微生物的出现成为肠脑功能的关键调节因素之一,并且使人们认识到微生物-肠-脑轴的重要性。肠道微生物和大脑通过免疫系统、色氨酸代谢、迷走神经和内分泌系统等多种途径相互联系。许多因素可以影响肠道微生物的组成,包括感染、分娩方式、抗生素药物的使用、压力和宿主遗传学。最近的研究表明肠道微生物可能与许多疾病有关,包括自闭症、肠易激综合征等。未来的研究将集中在了解微生物-肠道-脑轴的潜在机制,并试图阐明基于微生物的神经精神疾病的干预和治疗策略。The emergence of gut microbes has become one of the key regulatory factors of gut brain function,and has made people realize the importance of microbe gut brain axis.The gut microbiota and brain are interconnected through immune system,tryptophan metabolism,vagus nerve and endocrine system.Many factors can affect the composition of gut microbiota,including infection,mode of delivery,use of antibiotics,stress,and host genetics.Recent studies have shown that gut microbiota may be associated with many diseases,including autism,irritable bowel syndrome and so on.Future research will focus on understanding the underlying mechanisms of the microbial gut brain axis and attempt to elucidate microbial based intervention and treatment strategies for neuropsychiatric diseases.

关 键 词：微生物-肠-脑轴 短链脂肪酸 迷走神经 自闭症 

分 类 号：R741[医药卫生—神经病学与精神病学] R749[医药卫生—临床医学]