利他唑酮的晶体结构表征  

Crystal structure characteristics of litazolidone

作　　者：李进[1] 姚尚辰[1] 尹利辉[1] 许明哲[1] 胡昌勤[1] Li Jin;Yao Shang-Chen;Yin Li-Hui;Xu Ming-Zhe;Hu Chang-Qin(National Institutes for Food and Drug Control,102629)

机构地区：[1]中国食品药品检定研究院,北京102269

出　　处：《中国抗生素杂志》2021年第9期859-862,共4页Chinese Journal of Antibiotics

摘　　要：目的对利他唑酮的单晶结构进行表征。方法采用蒸汽扩散法制备利他唑酮单晶,并采用单晶X-ray衍射法测定单晶的结构。结果通过单晶数据的解析,确证了利他唑酮的绝对构型。结论该研究为利他唑酮及其他恶唑烷酮类药物的结构研究提供了技术参考。Objective To characterize the single crystal structure characteristics of litazolidone.Methods The single crystal of litazolidone was prepared by the steam diffusion method,and the crystal structure was determined by the single crystal X-ray diffraction method.Results The absolute configuration of litazolidone was confirmed by analyzing the single crystal data.Conclusion This study provided a reference for other related structure studies of litazolidone and other oxazolidinones.

关 键 词：利他唑酮 单晶培养 单晶X-ray衍射法 绝对构型 

分 类 号：R978.1[医药卫生—药品]