Efficacy of topical dorzolamide 2% in diabetic cystoid macular edema  

作　　者：Amani E Badawi Tharwat H.Mokbel Eman M Elhefney Sherein M.Hagras Ameera G Abdelhameed 

机构地区：[1]Department of Ophthalmology,Mansoura Ophthalmic Center,Faculty of Medicine,Mansoura University,Mansoura 35516,Egypt

出　　处：《International Journal of Ophthalmology(English edition)》2021年第9期1413-1418,共6页国际眼科杂志（英文版）

摘　　要：AIM:To study the effect of topical dorzolamide 2%on macular thickness reduction in diabetic cystoid macular edema(CME).METHODS:This was a prospective,non-randomized,open study including eyes with diabetic macular edema(DME).All eyes received topical dorzolamide 2%three times daily for one month.Changes in best-corrected visual acuity(BCVA),and central macular thickness(CMT)by optical coherence tomography were evaluated at 1 wk,1,and 3 mo post-treatment.RESULTS:Ninety-three eyes(84 patients)were included.Mean±SD(log MAR)BCVA improved significantly from 1.08±0.26 pretreatment to 0.66±0.24 at 1 mo and 0.87±0.26 at 3 mo post-treatment(P<0.001 both).The mean±SD CMT was significantly reduced from 535.27±97.4μm at baseline to 357.43±125.8μm at 1 mo and 376.23±114.5μm at 3 mo post-treatment(P<0.001 both).No significant ocular or systemic side effects were recorded.CONCLUSION:Topical dorzolamide 2%results in significant improvement of mean BCVA and reduction of mean CMT at 3 mo post-treatment.It can be used as an effective,affordable,and safe therapy for treatment of nonrefractory diabetic CME.

关 键 词：cystoid macular edema diabetic maculopathy DORZOLAMIDE RETINA 

分 类 号：R587.2[医药卫生—内分泌] R774.5[医药卫生—内科学]