Faecal immunochemical test outside colorectal cancer screening?  

作　　者：Noel Pin-Vieito Manuel Puga Daniel Fernández-de-Castro Joaquín Cubiella 

机构地区：[1]Department of Gastroenterology,Complexo Hospitalario Universitario de Ourense,Instituto de Investigación Sanitaria Galicia Sur,Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBERehd),Ourense 32005,Spain

出　　处：《World Journal of Gastroenterology》2021年第38期6415-6429,共15页世界胃肠病学杂志（英文版）

基　　金：Supported by Spain’s Carlos III Health Care Institute by Means of Project(Co-funded by European Regional Development Fund/European Social Fund"A way to make Europe"/"Investing in your future"),No.PI17/00837。

摘　　要：Faecal immunochemical tests(FITs)are the most widely colorectal cancer(CRC)diagnostic biomarker available.Many population screening programmes are based on this biomarker,with the goal of reducing CRC mortality.Moreover,in recent years,a large amount of evidence has been produced on the use of FIT to detect CRC in patients with abdominal symptoms in primary healthcare as well as in surveillance after adenoma resection.The aim of this review is to highlight the available evidence on these two topics.We will summarize the evidence on diagnostic yield in symptomatic patients with CRC and significant colonic lesion and the different options to use this(thresholds,brands,number of determinations,prediction models and combinations).We will include recommendations on FIT strategies in primary healthcare proposed by regulatory bodies and scientific societies and their potential effects on healthcare resources and CRC prognosis.Finally,we will show information regarding FIT-based surveillance as an alternative to endoscopic surveillance after high-risk polyp resection.To conclude,due to the coronavirus disease 2019 pandemic,FIT-based strategies have become extremely relevant since they enable a reduction of colonoscopy demand and access to the healthcare system by selecting individuals with the highest risk of CRC.

关 键 词：ADENOMA Colorectal cancer Diagnostic performance Faecal biomarkers Faecal haemoglobin Faecal immunochemical test Primary healthcare 

分 类 号：R735.34[医药卫生—肿瘤]