Serum phosphate and chronic kidney and cardiovascular disease: Phosphorus potential implications in general population  

作　　者：Vaia D Raikou 

机构地区：[1]Department of Nephrology,Doctors’Hospital,Athens 11257,Greece

出　　处：《World Journal of Nephrology》2021年第5期76-87,共12页世界肾病学杂志（英文版）

摘　　要：It has already been established that in end-stage renal disease,hyperphosphatemia causes soft tissue calcification including vascular calcifications.It has also been supported that there is a connection between increased serum pho-sphate and morbidity in subjects,who suffer from renal disease.However,studies in these populations conferred mixed results.Several warnings are included in the role of serum phosphorus on cardiovascular disease in normal populations.Homeostasis of serum phosphate is obtained by the cooperation between regulatory hormones,cellular receptors and bone metabolic factors.There is the probability that one or more phosphate regulatory factors,rather than phosphate directly,may be responsible for observed associations with calcifi-cation and cardiovascular events in normal populations.Experimental studies have shown that the restriction of dietary phosphate prevents the pro-gression of kidney dysfunction,although high dietary phosphate aggravates the renal function.In the current review,we discuss the role of serum phosphorus on progression of renal dysfunction and cardiovascular outcomes in chronic kidney disease patients and its involvement in important health risks in the general population.

关 键 词：PHOSPHORUS Renal insufficiency CHRONIC DIALYSIS Cardiovascular diseases 

分 类 号：R69[医药卫生—泌尿科学]