Clinical outcome after surgery on schwannomas in the extremities  

作　　者：Andreas Saine Granlund Michala Skovlund Sørensen Claus Lindkær Jensen Birthe Højlund Bech Michael Mørk Petersen 

机构地区：[1]Musculoskeletal Tumor Section,Department of Orthopedic Surgery,Copenhagen University Hospital,Rigshospitalet,Copenhagen 2100,Denmark [2]Department of Orthopedic Surgery,Copenhagen University Hospital,Copenhagen 2200,Denmark [3]Musculoskeletal Tumor Section,Department of Orthopedic Surgery,University of Copenhagen,Copenhagen 2100,Denmark [4]Department of Radiology,Rigshospitalet,University of Copenhagen,Copenhagen 2100,Denmark

出　　处：《World Journal of Orthopedics》2021年第10期760-767,共8页世界骨科杂志（英文版）

摘　　要：BACKGROUND Schwannoma is a benign,encapsulated and slowly growing tumor originating from Schwann cells and is rarely seen in the peripheral nerve system.Typical symptoms are soreness,radiating pain and sensory loss combined with a soft tissue mass.AIM To evaluate pre-and postoperative symptoms in patients operated for schwannomas in the extremities and investigate the rate of malignant transformation.METHODS In this single center retrospective study design,all patients who had surgery for a benign schwannoma in the extremities from May 1997 to January 2018 were included.The location of the tumor in the extremities was divided into five groups;forearm,arm,shoulder,thigh and leg including foot.The locations of the tumor in the nerves were also categorized as either;proximal,distal,minor or major nerve.During the pre-and postoperative clinical evaluation,symptoms were classified as paresthesia,local pain,radiating pain,swelling,impairment of mobility/strength and asymptomatic tumors that were found incidentally(with magnetic resonance imaging).The patients were evaluated after surgery using the following categories:Asymptomatic or symptomatic patients(radiating and/or local pain)and those with complications.The follow up period was from the time of surgery until last examination of the particular physician.Multivariate logistic regression analysis was performed to identify independent prognostic factors for postoperative significant symptoms at follow-up.RESULTS We identified 858 cases from the institutional pathology register.We excluded cases with duplicate diagnoses(n=407),pathology not including schwannomas(n=157),lesions involving the torso,spine and neck(n=150)leaving 144 patients for further analysis.In this group 99 patients underwent surgery and there were five complications recorded:2 infections(treated with antibiotics)and 3 nerve palsies(2 involving the radial nerve and one involving the median nerve)that recovered spontaneously.At the end of follow-up,1.4 mo(range 0.5-76)postoperatively,we recorded a po

关 键 词：SCHWANNOMA EXTREMITIES SURGERY Removal SYMPTOMS OUTCOME 

分 类 号：R739.96[医药卫生—肿瘤]