血清白细胞介素⁃6水平对非病毒性肝细胞癌患者预后的影响  

Effect of serum IL⁃6 level on the prognosis of the patients with non⁃viral hepatocellular carcinoma

作　　者：吴鸿燕 常志娟 邹玲莉 冷远景 Wu Hongyan;Chang Zhijuan;Zou Linli;Leng Yuanjing(No.3 Convalescent Zone of Special Service Sanatorium Center of Air Force,Hangzhou Military Command,Hangzhou 310002,China)

机构地区：[1]空军杭州疗养特勤中心疗养三区,浙江杭州310002 [2]九江学院附属医院泌尿外科

出　　处：《海军医学杂志》2021年第5期553-556,共4页Journal of Navy Medicine

摘　　要：目的研究血清白细胞介素⁃6(IL⁃6)对非病毒性肝细胞癌(HCC)患者预后的影响。方法选择2009年1月1日至2015年12月31日在九江学院附属医院消化内科和肝胆外科被诊断为非病毒性HCC的患者共107名,本研究的随访终点是患者死亡,观察时间不少于3个月。通过随访终点将患者分为2组,分别为存活组和死亡组,分析影响患者生存的因素。采用酶联免疫吸附测定法定量检测血清IL⁃6水平。根据血清IL⁃6的中位水平对患者进行分层,以分析其对生存的影响。同时采用多变量分析评估IL⁃6对非病毒性HCC患者预后的影响。结果血清IL⁃6水平[风险比(HR):1.96,95%CI:1.06~3􀆰13,P<0.01]、肿瘤分期(HR:2.14,95%CI:1.13~3.59,P<0.01)及血清谷丙转氨酶水平(HR:1.21,95%CI:0.84~1.93,P<0.01)是非病毒性HCC患者生存的独立预测因素。高IL⁃6组的5年生存率(25.42%)显著低于低IL⁃6组(43􀆰75%),差异有统计学意义(P<0.05)。结论高血清IL⁃6水平是非病毒性HCC患者预后不良的独立因素。Objective To investigate the effect of interleukin⁃6(IL⁃6)on the prognosis of the patients with non⁃viral hepato⁃cellular carcinoma(HCC).Methods A total of 107 confirmed non⁃viral HCC patients who stayed in the hospital from January 1,2009 to December 31,2015,were enrolled as research subjects.The observation time of the patients was no less than 3 months,with death as the end of follow⁃up time.By follow⁃up end time,the patients were divided into the survival group and the death group.Analy⁃ses were made on the factors affecting survival of the patients.The serum IL⁃6 levels were quantified by enzyme⁃linked immunosorbent assay(ELASA).The patients were stratified according to the median levels of serum IL⁃6 to determine its impact on survival.At the same time,multivariate analysis was also applied to assess the impact of IL⁃6 on the prognosis of the patients with non⁃viral HCC.Results Serum IL⁃6 levels(HR:1.96,95%CI:1.06⁃3.13,P<0.01),tumor stage(HR:2.14,95%CI:1.13⁃3.59,P<0.01)and serum alanine aminotransferase levels(HR:1.21,95%CI:0.84⁃1.93,P<0.01)were independent predictors of survival in the patients with non⁃viral HCC.In addition,the survival rate of the high IL⁃6 group was significantly lower than that of the low IL⁃6 group(5⁃year survival rate:25.42%vs 43.75%,P<0.05),with statistical significance(P<0.05).Conclusion High serum IL⁃6 level is an independent factor for poor prognosis of the patients with non⁃viral HCC.

关 键 词：白细胞介素⁃6 肝细胞癌 生存 非乙型肝炎和非丙型肝炎病毒 

分 类 号：R735.7[医药卫生—肿瘤]