尤瑞克林联合丹参多酚酸治疗大动脉粥样硬化性脑梗死临床疗效  

Clinical efficacy of urinary kallidinogenase combined with salvia miltiorrhiza polyphenolic acid in the treatment of large artery atherosclerotic cerebral infarction

作　　者：张洪波[1] 陈冬霞[1] 冯青芝[1] 邢世珠 郝娜娜[1] Zhang Hongbo;Chen Dongxia;Feng Qingzhi;Xing Shizhu;Hao Nana(Sanmenxia Central Hospital,Sanmenxia 472000,Henan,China)

机构地区：[1]三门峡市中心医院,河南三门峡472000

出　　处：《临床心身疾病杂志》2021年第5期13-17,共5页Journal of Clinical Psychosomatic Diseases

摘　　要：目的探讨尤瑞克林联合丹参多酚酸治疗大动脉粥样硬化性脑梗死临床疗效。方法将103例大动脉粥样硬化性脑梗死患者按照随机数字表法分为研究组52例与对照组51例。两组均在常规治疗基础上给予尤瑞克林,研究组在此基础上给予丹参多酚酸,观察14 d。治疗前后采用美国国立卫生研究院卒中量表及日常生活能力量表评定两组神经功能及日常生活能力,比较两组临床疗效,比较治疗前后两组脑血流动力学指标、脂蛋白相关磷脂酶A2、缺血修饰白蛋白、血液流变学指标水平,比较两组不良反应发生率。结果治疗后两组美国国立卫生研究院卒中量表评分均较治疗前显著降低(P<0.01),日常生活能力量表评分均较治疗前显著升高(P<0.01),研究组较对照组变化更显著(P<0.01)。研究组治疗总有效率显著高于对照组(P<0.05)。治疗后两组大脑后动脉、大脑中动脉、大脑前动脉水平均较治疗前显著升高(P<0.01),研究组显著高于对照组(P<0.01);两组缺血修饰白蛋白及脂蛋白相关磷脂酶A2水平均较治疗前显著降低(P<0.01),研究组显著低于对照组(P<0.01);两组血浆黏度、全血低切黏度、全血高切黏度、红细胞聚集指数均较治疗前显著降低(P<0.01),研究组显著低于对照组(P<0.01)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论尤瑞克林联合丹参多酚酸治疗大动脉粥样硬化性脑梗死效果显著,可调节缺血修饰白蛋白、脂蛋白相关磷脂酶A2水平,改善血液流变学及脑血流动力学状态,有助于恢复神经功能及日常生活能力,安全性高。Objective To investigate the clinical efficacy of urinary kallidinogenase combined with salvia miltiorrhiza polyphenolic acid in the treatment of large artery atherosclerotic cerebral infarction.Methods A total of 103 patients with large artery atherosclerotic cerebral infarction were divided into study group(52 cases)and control group(51 cases)according to random number table method.Both groups were given urinary kallidinogenase on the basis of conventional treatment,and the study group was given salvia miltiorrhiza polyphenolic acid on this basis for 14 days.National institute of health stroke scale(NIHSS)and activity of daily living scale(ADL)were used to assess neurological function and daily living ability before and after treatment.The clinical effects of the two groups were compared,the levels of cerebral hemodynamic indexes,lipoprotein-associated phospholipase A2(Lp-PLA2),ischemia modified albumin(IMA)and hemorheology indexes of the two groups before and after treatment were compared,and the incidence of adverse reactions between the two groups was compared.Results After treatment,the NIHSS scores of the two groups were significantly lower than those before treatment(P<0.01),and the ADL scores were significantly higher than those before treatment(P<0.01).The change of study group was more significant than control group(P<0.01).The total effective rate in study group was significantly higher than that in control group(P<0.05).After treatment,posterior cerebral artery(PCA),middle cerebral artery(MCA)and anterior cerebral artery(ACA)levels in the two groups were significantly higher than those before treatment(P<0.01),and the study group was significantly higher than the control group(P<0.01).The levels of ischemia modified albumin(IMA)and Lp-PLA2 in the two groups were significantly lower than those before treatment(P<0.01),and the study group was significantly lower than the control group(P<0.01).The plasma viscosity,whole blood low-shear viscosity,whole blood high-shear viscosity,and erythrocyte aggregati

关 键 词：大动脉粥样硬化性脑梗死 尤瑞克林 丹参多酚酸 神经功能 生活能力 

分 类 号：R743.1[医药卫生—神经病学与精神病学]