幽门螺杆菌感染对帕金森病患者运动症状、便秘评分和生活质量的影响  

Effects of Helicobacter Pylori Infection on Motor Symptoms,Constipation Score and Quality of Life of Patients with Parkinson′s Disease

作　　者：王少颖[1] 王莉迪 曹玉娇 李净兵[1] 赵璨[1] 刘翠青[1] 王青青[1] WANG Shaoying;WANG Lidi;CAO Yujiao;LI Jingbing;ZHAO Can;LIU Cuiqing;WANG Qingqing(Department of Neurology,the Eighth People′s Hospital of Hebei Province/Hebei Geriatric Hospital,Shijiazhuang 050011,China)

机构地区：[1]河北省第八人民医院河北省老年病医院神经内科,石家庄050011

出　　处：《医学综述》2021年第18期3717-3721,共5页Medical Recapitulate

基　　金：河北省医学科学研究课题(20190980)。

摘　　要：目的探讨幽门螺杆菌(Hp)感染对帕金森病(PD)患者运动症状、便秘评分和生活质量的影响。方法选取2015年9月至2018年9月河北省第八人民医院神经内科收治的80例PD合并Hp感染患者作为Hp感染组,选取同期性别、年龄、病程相匹配的80例未感染Hp的PD患者作为无Hp感染组。比较两组Hoehn-Yahr(H-Y)分级、统一帕金森病评定量表(UPDRS)-Ⅲ评分、UPDRS-Ⅳ评分、便秘Wexner评分和39项帕金森病生活质量调查表(PDQ39)评分。无Hp感染PD患者予常规治疗,Hp感染PD患者在常规治疗基础上给予根除Hp治疗。比较Hp感染患者治疗前后H-Y分级、UPDRS-Ⅲ评分、UPDRS-Ⅳ评分、便秘Wexner评分及PDQ39评分。统计Hp感染患者的Hp根除率,并比较治疗后Hp根除与未根除患者运动症状治疗有效率及上述指标差异。结果Hp感染组患者的H-Y分级、UPDRS-Ⅲ评分、UPDRS-Ⅳ评分、便秘Wexner评分和PDQ39评分均高于无Hp感染组(P<0.05或P<0.01)。治疗后,Hp感染患者H-Y分级、UPDRS-Ⅲ评分、UPDRS-Ⅳ评分、便秘Wexner评分和PDQ39均低于治疗前[(2.67±0.32)级比(3.20±0.45)级,(23.21±4.41)分比(31.72±4.24)分,(2.42±0.50)分比(3.20±0.57)分,(7.43±2.40)分比(10.54±2.30)分,(34.67±8.14)分比(40.12±10.32)分](P<0.01)。Hp感染患者中Hp根除64例,Hp根除患者的运动症状临床有效率为46.88%(30/64),高于Hp未根除患者的6.25%(1/16)(P<0.01)。Hp根除组患者的UPDRS-Ⅲ评分、UPDRS-Ⅳ评分、便秘Wexner和PDQ39评分均低于Hp未根除组(P<0.05或P<0.01)。结论Hp感染在PD患者中检出率较高,积极根除Hp能够有效改善PD患者的运动症状及运动并发症,缓解便秘,提高生活质量。Objective To investigate the effect of Helicobacter pylori(Hp)infection on motor symptoms,constipation score and quality of life of patients with Parkinson′s disease(PD).Methods A total of 80 PD patients with Hp infection admitted to the Department of Neurology of the Eighth People′s Hospital of Hebei Province from Sep.2015 to Sep.2018 were included as an Hp infection group;80 PD patients with matched age,sex,and course of disease who were not infected with Hp during the same period were included as a non-Hp infection group.The Hoehn Yahr(H-Y)grading scale,unified Parkinson′s disease rating scale(UPDRS)partⅢandⅣscores,constipation Wexner score and 39-item Parkinson′s disease questionnaire(PDQ39)scores of the two groups were compared.The PD patients without Hp infection were given routine treatment,and the PD patients with Hp infection were given Hp eradication treatment on the basis of the routine treatment.H-Y grade,UPDRS-Ⅲscore,UPDRS-Ⅳscore,constipation Wexner score and PDQ39 score were compared before and after treatment in the patients with Hp infection.The eradication rate of Hp infected patients was recorded,and the effective rate of treatment of motor symptoms and the difference of the above indexes between patients with Hp-eradication and patients without Hp-eradication after treatment were compared.Results The H-Y grade,UPDRS-Ⅲscore,UPDRS-Ⅳscore,Wexner score of constipation and PDQ39 score of the Hp infection group were higher than those of the non-Hp infection group(P<0.05 or P<0.01).After treatment,the H-Y score,UPDRS-Ⅲscore,UPDRS-Ⅳscore,Wexner score of constipation and PDQ39 of the patients with Hp infection were lower than those before treatment[(2.67±0.32)grade vs(3.20±0.45)grade,(23.21±4.41)vs(31.72±4.24),(2.42±0.50)vs(3.20±0.57),(7.43±2.40)vs(10.54±2.30),(34.67±8.14)vs(40.12±10.32)](P<0.01).Among the patients with Hp infection,64 cases of Hp were eradicated,and the clinical effective rate of motor symptoms in patients with Hp-eradication was 46.88%,which was highe

关 键 词：帕金森病 幽门螺杆菌 运动症状 便秘 生活质量 

分 类 号：R742.5[医药卫生—神经病学与精神病学]