肺瘤消积方对痰淤互结型非小细胞肺癌患者癌因性疲乏的防治作用研究  

Study of Feiliu Xiaoji Recipe on cancer-related fatigue in patients with non-small cell lung cancer of phlegm-blood stasis

作　　者：赵芳 王振强 张庆江 赵阳 陈晶晶 董雪珊 李小江[3] ZHAO Fang;WANG Zhenqiang;ZHANG Qingjiang;ZHAO Yang;CHEN Jingjing;DONG Xueshan;LI Xiaojiang(Hebei University of Chinese Medicine,Shijiazhuang,Hebei 050091;不详)

机构地区：[1]河北中医学院研究生学院,河北石家庄050091 [2]河北中医学院附属沧州中西医结合医院中医内科,河北沧州061001 [3]天津中医药大学第一附属医院肿瘤科,天津300193

出　　处：《河北中医》2021年第6期922-925,929,共5页Hebei Journal of Traditional Chinese Medicine

摘　　要：目的观察肺瘤消积方对痰瘀互结型非小细胞肺癌(NSCLC)患者癌因性疲乏(CRF)的防治作用。方法将100例痰瘀互结型NSCLC患者按照随机数字表法分为2组。对照组50例采用常规化疗方案,并给予对症处理,治疗组50例在对照组治疗基础上予肺瘤消积方口服。2组均治疗4个化疗周期。比较2组治疗前后中医证候评分、Karnofsky评分(KPS)、简易疲乏量表(BFI)评分,并统计2组疗效。结果治疗组总有效率86.00%(43/50),对照组总有效率68.00%(34/50),治疗组疗效优于对照组(P<0.05)。治疗后2组中医证候各项评分均较本组治疗前降低(P<0.05),且治疗后治疗组均低于对照组(P<0.05)。治疗后2组KPS均较本组治疗前降低(P<0.05),对照组BFI评分升高(P<0.05),且治疗后治疗组KPS高于对照组(P<0.05),BFI评分低于对照组(P<0.05)。治疗组治疗后BFI评分升高,但与本组治疗前比较差异无统计学意义(P>0.05)。结论肺瘤消积方对痰瘀互结型NSCLC患者CRF具有良好的治疗作用,同时对化疗起到辅助作用,改善患者的KPS评分。Objective To observe the therapeutic effect of Feiliu Xiaoji Recipe on cancer-related fatigue(CRF)in patients with non-small cell lung cancer(NSCLC)of phlegm-blood stasis.Methods Totally 100 NSCLC participants were randomly divided into two groups,50 cases in control group were treated with conventional chemotherapy,50 cases in treatment group with Feiliu Xiaoji Recipe on the base of control group,additionally.After 4 cycles of chemotherapy,TCM symptom score,Karnofsky Performance Scale(KPS)score,and Brief Fatigue Inventory(BFI)score,and the clinical effects were compared between groups.Results After treatment,the total effective rate was higher in treatment group than in control group[86.00%(43/50)vs 68.00%(34/50),(P<0.05),respectively];from the perspective of the situation in the group,the TCM symptom scores and KPS scores were lower than those before chemotherapy(P<0.05),and TCM symptom scores in treatment group were significantly decreased(P<0.05);but KPS scores in treatment group were significantly increased(P<0.05);BFI scores were higher than those before chemotherapy(P<0.05),which in treatment group was significantly decreased(P<0.05),and no statistical significance in group was observed between after and before treated(P>0.05).Conclusion For patients NSCLC with phlegm-blood stasis,Feiliu Xiaoji Recipe has a good therapeutic effect on CRF caused by chemotherapy,with assisting chemotherapy and improving KPS score.

关 键 词：癌 非小细胞肺 疲劳 中药疗法 

分 类 号：R734.2[医药卫生—肿瘤]