靶向CXCR4 PET/CT分子探针在肿瘤诊疗中的应用进展  

Progress of CXCR4 targeted PET/CT molecular probe and its application in tumor

作　　者：孙芳芳[1] 杜雪梅(审校)[1] SUN Fangfang;DU Xuemei(Department of Nuclear Medicine,First Affiliate Hospital of Dalian Medical University,Dalian 116022,China)

机构地区：[1]大连医科大学附属第一医院核医学科,大连116022

出　　处：《国际医学放射学杂志》2021年第5期584-588,共5页International Journal of Medical Radiology

摘　　要：趋化因子受体4(CXCR4)在许多肿瘤细胞表面高表达,它可以作为肿瘤干细胞的标志物,其表达与肿瘤的恶性程度及病人的预后直接相关。靶向CXCR4 PET/CT显像在疾病的诊断、CXCR4靶向治疗病例选择、疗效评价等方面具有很大的应用潜力。就靶向CXCR4 PET/CT分子探针及其在肿瘤诊疗中的应用研究进展进行综述,总结分析各种探针的特点及临床转化情况,为CXCR4临床应用转化提供帮助。Chemokine receptor 4(CXCR4),highly expressed on the surfaces of various tumor cells,can be used as a marker of tumor stem cells.The expression of CXCR4 correlates with the tumor malignancy and the prognosis of patients.CXCR4 as a target for PET/CT imaging shows great potentials in the disease diagnosis,case selection for CXCR4-target treatment and the evaluation of therapeutic effect.We reviewed the research progresses of targeted CXCR4 PET/CT molecular probe and its application in tumor diagnosis and treatment,summarized the characteristics and clinical transformation of various probes,so as to provide help for the clinical application and transformation of CXCR4.

关 键 词：趋化因子受体4 分子探针 正电子发射体层成像 肿瘤 

分 类 号：R73[医药卫生—肿瘤] R445.3[医药卫生—临床医学]