Time to give up traditional methods for the management of gastrointestinal neuroendocrine tumours  

作　　者：Ahmet Yozgat Murat Kekilli Mustafa Altay 

机构地区：[1]Department of Gastroenterology,Ufuk University,Ankara,06510,Turkey [2]Department of Gastroenterology,Gazi University,Ankara 06560,Turkey [3]Department of Endocrinology and Metabolism,University of Health Sciences Turkey,Keçiören Health Administration and Research Center,Ankara 06190,Turkey

出　　处：《World Journal of Clinical Cases》2021年第29期8627-8646,共20页世界临床病例杂志

摘　　要：Neuroendocrine tumors(NETs)are a rare and heterogeneous disease group and constitute 0.5%of all malignancies.The annual incidence of NETs is increasing worldwide.The reason for the increase in the incidence of NETs is the detection of benign lesions,incidental detection due to the highest use of endoscopic and imaging procedures,and higher recognition rates of pathologists.There have been exciting developments regarding NET biology in recent years.Among these,first of all,somatostatin receptors and downstream pathways in neuroendocrine cells have been found to be important regulatory mechanisms for protein synthesis,hormone secretion,and proliferation.Subsequently,activation of the mammalian target of rapamycin pathway was found to be an important mechanism in angiogenesis and tumor survival and cell metabolism.Finally,the importance of proangiogenic factors(platelet-derived growth factor,vascular endothelial growth factor,fibroblastic growth factor,angiopoietin,and semaphorins)in the progression of NET has been determined.Using the combination of biomarkers and imaging methods allows early evaluation of the appropriateness of treatment and response to treatment.

关 键 词：Enterochromaffin cells 68Ga-DOTATATE GASTROINTESTINAL Neuroendocrine tumours Somatostatin receptor Targeted peptide receptor radiotherapy 

分 类 号：R735[医药卫生—肿瘤]