Disseminated soft tissue diffuse large B-cell lymphoma involving multiple abdominal wall muscles:A case report  

作　　者：Chang-Hoon Lee So-Yeon Jeon Ho-Young Yhim Jae-Yong Kwak 

机构地区：[1]Department of Internal Medicine,Jeonbuk National University Medical School,Jeonju 54907,South Korea

出　　处：《World Journal of Clinical Cases》2021年第28期8557-8562,共6页世界临床病例杂志

摘　　要：BACKGROUND Diffuse large B-cell lymphoma(DLBCL)is the most common subtype of non�Hodgkin lymphoma,and patients with DLBCL typically present rapidly growing masses.Lymphoma involving muscle is rare and accounts for only 5%;furthermore,multiple muscles and soft tissue involvement of DLBCL is unusual.Due to unusual clinical manifestation,accurate diagnosis could be delayed.CASE SUMMARY A 61-year-old man complained of swelling,pain and erythematous changes in the lower abdomen.Initially,soft tissue infection was suspected,however,skin lesion did not respond to antibiotics.18Fluoro-2-deoxy-D-glucose(18F-FDG)positron emission tomography-computed tomography demonstrated FDG uptake not only in the skin and subcutaneous tissue of the abdomen but also in the abdominal wall muscles,peritoneum,perineum,penis and testis.DLBCL was confirmed by biopsy of the abdominal wall muscle and subcutaneous tissue.After intensive treatment including chemotherapy with rituximab,cyclophosphamide,doxorubicin,vincristine and prednisolone,central nervous system prophylaxis(intrathecal injection of methotrexate,cytarabine and hydrocortisone)and orchiectomy,he underwent peripheral blood stem cell mobilization for an autologous hematopoietic stem cell transplantation.Despite intensive treatment,the disease progressed rapidly and the patient showed poor outcome(overall survival,9 mo;disease free survival,3 mo).CONCLUSION The first clinical manifestation of soft tissue DLBCL involving multiple muscles was similar to the infection of the soft tissue.

关 键 词：Primary extranodal diffuse large B-cell lymphoma Soft tissue lymphoma Disseminated muscles and soft tissue invasion Atypical presentation of diffuse large B�cell lymphoma Central nervous system relapse Case report 

分 类 号：R733.1[医药卫生—肿瘤]