口腔鳞癌Survivin表达及其在血管生成中的作用  

Study of survivin expression and angiogenesis in oral squamous cell carcinoma

作　　者：李腾宇 张霞[1] 于肖鹏[1] 李晓光[1] 王西冉 王延秀[2] 刘焕燕 Li Tengyu;Zhang Xia;Yu Xiaopeng;Li Xiaoguang;Wang Xiran;Wang yanxiu;Liu Huanyan(Department of Stomatology,Taian City Central Hospital,Taian 271000,China;Department of Pain Medicine,Taian City Central Hospital,Taian 271000,China)

机构地区：[1]泰安市中心医院口腔科,山东泰安271000 [2]泰安市中心医院疼痛科,山东泰安271000

出　　处：《山东第一医科大学（山东省医学科学院）学报》2021年第9期667-669,共3页Journal of Shandong First Medical University ＆ Shandong Academy of Medical Sciences

基　　金：山东省科学技术发展计划(2011GGH21822);泰安市科技局资助项目(2016NS1092)。

摘　　要：目的研究口腔鳞癌(oral squamous cell carcinoma,OSCC)中生存素(Survivin)的表达及其在血管生成中的作用。方法采用免疫组织化学方法,检测OSCC标本中Survivin、环氧化酶-2(COX-2)、血管内皮生长因子(VEGF)及CD34的表达,并测定其微血管密度值(MVD)。SPSS22.0软件行统计学分析。结果106例OSCC组织中,Survivin与COX-2、VEGF表达明显相关(P<0.05)。Survivin阳性组MVD值高于阴性组(P<0.01)。结论Survivin促进了OSCC组织的血管生成,COX-2和VEGF参加了其作用。Objective:To explore the relationships between Survivin expression and angiogenesis in oral squamous cell carcinoma.Methods:The Survivin,COX-2,VEGF and CD34 expressions were evalulated by immunohistochemical method.Results:The expressions of Survivin and COX-2,VEGF in oral squamous cell carcinoms were significantly positively correlated(P<0.05).There was significant difference of MVD between Survivin positive oral squamous cell carcinoma and negative ones(P<0.01).Conclusion:The present findings suggest that there is some link between Survivin and angiogenesis in oral squamous cell carcinom,partly attributing to the effect of COX-2 and VEGF.

关 键 词：口腔鳞癌 生存素 环氧化酶-2 CD34 血管内皮生长因子 

分 类 号：R739.8[医药卫生—肿瘤]