上皮间质转换标志物在胃癌中的表达及与Her-2的关系  

Expression of Epithelial-Mesenchymal Transition in Gastric Carcinoma and Its Relationship with Her-2

作　　者：王贺[1] 申志华 薛润国[1] 刘海丽[1] 谢静 WANG He;SHEN Zhihua;XUE Runguo(Chengde Central Hospital, Hebei Chengde 067000, China)

机构地区：[1]河北省承德市中心医院,河北承德067000

出　　处：《河北医学》2021年第10期1608-1612,共5页Hebei Medicine

基　　金：河北省承德市科技计划项目,(编号:202002A008)。

摘　　要：目的:观察在胃癌中E-cadherin和Vimentin这两种上皮间质转化(epithelial-mesenchymal transition,EMT)标记物和Her-2的表达情况,分析EMT与胃癌临床病理特征的关系及与Her-2表达的关系。方法:采用免疫组化检测EMT标记物E-cadherin和Vimentin在198例胃癌中的表达情况;同时检测胃癌中Her-2的表达情况与EMT之间的关系。结果:胃癌中Vimentin表达高于癌旁组织,E-cadherin表达低于癌旁组织,差异具有统计学意义(P<0.05);E-cadherin和Vimentin的表达与年龄、性别无关(P>0.05);E-cadherin和Vimentin的表达与肿瘤分化程度、浸润深度及是否有淋巴结转移有关(P<0.05);Vimentin在Her-2阳性的胃癌组织中的表达高于Her-2阴性的组织,而E-cadherin在Her-2阳性的胃癌组织中的表达低于Her-2阴性的组织,差异具有统计学意义(P<0.05)。结论:EMT现象在胃癌的发生、发展过程中发挥作用;在胃癌中,Her-2的表达对EMT标志物表达有所影响。Objective:To observe the expression of E-cadherin and Vimentin,two epithelial-mesenchymal transition(EMT)markers and Her-2 in gastric cancer,and analyze the relationships between EMT and the clinicopathological characteristics of gastric cancer and between EMT and Her-2 expression.Methods:Immunohistochemistry was used to detect the expression of EMT markers E-cadherin and Vimentin in 198 cases of gastric cancer;at the same time,the relationship between the expression of Her-2 and EMT in gastric cancer was detected.Results:The expression of Vimentin in gastric cancer was higher than that of adjacent tissues,and the expression of E-cadherin was lower than that of adjacent tissues.The difference was statistically significant(P<0.05);The expression of E-cadherin and Vimentin had nothing to do with age and gender(P>0.05);the expression of E-cadherin and Vimentin is related to the degree of tumor differentiation,depth of invasion and lymph node metastasis(P<0.05);The expression of Vimentin in Her-2 positive gastric cancer tissues is higher than Her-2 negative tissues.The expression of E-cadherin in Her-2 positive gastric cancer tissue was lower than that in Her-2 negative tissue,and the difference was statistically significant(P<0.05).Conclusion:EMT phenomenon plays a role in the occurrence and development of gastric cancer;in gastric cancer,the expression of Her-2 influenced the expression of EMT markers.

关 键 词：上皮间质转换 胃癌 人表皮生长因子2 

分 类 号：R73[医药卫生—肿瘤]