复方樟柳碱注射液对非增生性糖尿病视网膜病变VEGF IGF-1的影响  

Effect of Compound Anisodine Hydrobromide Injection on VEGF and IGF-1 in Patients with Non Proliferative Diabetic Retinopathy

作　　者：王芬芬 马卫国[1] 殷小红 谢传庆 乔瑛[2] 燕洁静 曹燕 WANG Fenfen;MA Weiguo;YIN Xiaohong(The First Affiliated Hospital of Xi'an Medical College, Shaanxi Xi'an 710077, China)

机构地区：[1]西安医学院第一附属医院内分泌科,陕西西安710077 [2]陕西省西安市第一医院眼科,陕西西安710002 [3]陕西省眼科研究所,陕西西安710004

出　　处：《河北医学》2021年第10期1622-1626,共5页Hebei Medicine

基　　金：陕西省重点研发计划项目,(编号:S2019-YF-YBSF-0180)。

摘　　要：目的:探讨复方樟柳碱对非增生性糖尿病视网膜病变的治疗效果,为其应用提供参考。方法:按简单随机抽样且人工分层将2018年9月至2020年9月西安医学院第一附属医院收治的146例非增生性糖尿病视网膜病变患者分为两组,每组73例。对照组给予全视网膜激光光凝(PRP)和常规治疗,观察组加用复方樟柳碱治疗,比较治疗前后临床体征(出血吸收、水肿消失及渗出吸收时间)、眼底指标[视力、出血面积、渗出面积、微血管瘤数量、30o范围内视野平均阈值敏感度(MS)、视网膜振荡电位总波幅值(oPs)]、血管内皮生长因子(VEGF)、类胰岛素一号生长因子(IGF-1)等水平变化及临床疗效。结果:治疗后观察组总有效率(95.89%)高于对照组(75.34%)(χ2=18.048,P=0.000)。观察组出血吸收时间、水肿消失时间及渗出吸收时间均明显短于对照组,同时出血面积、渗出面积也要小于对照组(P<0.05)。治疗前后差值来看,观察组在视力、MS、oPs总波幅值差值上升幅度明显大于对照组(P<0.05)且微血管瘤减少幅度明显大于对照组(P<0.05)。观察组在VEGF、IGF-1降低幅度上明显要大于对照组(P<0.05)。结论:复方樟柳碱能有效改善非增生性糖尿病视网膜病变患者临床症状,调节血管内皮生长因子与类胰岛素一号生长因子水平,促进眼部微循环。Objective:To investigate the therapeutic effect of compound anisodine on non-proliferative diabetic retinopathy,and to provide reference for its application.Methods:According to simple random sampling and manual stratification,146 patients with non-proliferative diabetic retinopathy admitted to the First Affiliated Hospital of Xi'an Medical College from September 2018 to September 2020 were divided into 2 groups,with 73 cases in each group.The control group was treated with total retinal laser photocoagulation(PRP)+conventional treatment,and the observation group was treated with compound camphorine,comparison before and after treatment clinical signs(hemorrhage,edema disappeared and effusion absorption time),fundus index[vision,bleeding area,seepage area,number of micro hemangioma,within the scope of 30 o view the average sensitivity threshold(MS),retinal oscillation potential total amplitude values(oPs)],vascular endothelial growth factor(VEGF)and insulin-like growth factor number one(IGF 1)level change and clinical curative effect.Results:After treatment,the total effective rate of observation group(95.89%)was higher than that of control group(75.34%)(χ2=18.048,P=0.000).The bleeding absorption time,edema disappearance time and exudation absorption time in the observation group were significantly shorter than those in the control group,while the bleeding area and exudation area were also smaller than those in the control group(P<0.05).In terms of the difference before and after treatment,the increase in visual acuity,MS,and oPs total wave amplitude difference in the observation group was significantly greater than that in the control group(P<0.05),and the reduction of microangioma was significantly greater than that in the control group(P<0.05).The observation group had significantly greater reductions in VEGF and IGF-1 than the control group(P<0.05).Conclusion:Compound anisodine can effectively improve the clinical symptoms of patients with non-proliferative diabetic retinopathy,regulate the levels of vascula

关 键 词：糖尿病视网膜病变 全视网膜激光光凝 复方樟柳碱 血管内皮生长因子 

分 类 号：R73[医药卫生—肿瘤]