前庭神经炎患者25羟维生素D和C反应蛋白水平的研究  

25-Hydroxyvitamin D and C-reactive protein levels in Patients with Vestibular Neuritis

作　　者：李秀花[1] 孟萌 宋江曼 田珊珊 徐长波[1] LI Xiuhua;MENG Meng;SONG Jiangman(Department of Neurology,NO. 731 Hospital of CASIC,Beijing 100074,China)

机构地区：[1]中国航天科工集团七三一医院神经内科,北京100074

出　　处：《中风与神经疾病杂志》2021年第9期829-832,共4页Journal of Apoplexy and Nervous Diseases

摘　　要：目的分析急性前庭神经炎和健康对照组血清25羟维生素D(25(OH)D)及C反应蛋白的(CRP)水平,并分析二者与前庭神经炎(VN)的相关性。方法在2019年3月至2020年8月之间,航天731医院共收治了46例在症状发作7 d内被诊断为VN的患者,同时招募了66例年龄和性别相匹配的健康对照者。记录所有受试者的年龄,性别,身高,体重,生活习惯,持续的健康问题和用药史,并测量和比较25(OH)D和CRP的水平。结果VN患者的血清25(OH)D水平显著低于对照组(18.30±6.19 vs.22.43±5.23 ng/ml,P<0.001),而CRP水平显著高于对照组(15.86±8.37 vs.ng/ml,P<0.001)。回归分析表明,25(OH)D及CRP与VN的患病相关,比值比分别为1.187(95%CI=1.046~1.093,P=0.001),1.223(95%CI=1.10~1.36,P=0.000)。结论前庭神经炎是一种急性炎症反应,在前庭神经炎患者中25(OH)D水平降低,CRP水平升高。Objective We evaluated serum levels of 25-hydroxyvitamin D(25(OH)D)and C-reactive protein(CRP)in patients presenting acutely with Vestibular neuritis(VN)and healthy controls and investigated the possible correlation of serum 25(OH)D and CRP levels with VN.Methods A total of 46 consecutive patients diagnosed with VN within 7 days of symptom onset and 66 age-and sex-matched healthy controls in NO731 Hospital,between March 2019 and August 2020 were recruited.Demographic and clinical data,such as age,sex,height,weight,living habits,ongoing health problems,and medication history,for all subjects were recorded,and levels of 25(OH)D and CRP were measured and compared.Results Serum levels of 25(OH)D were significantly lower in patients with VN than in controls(18.30±6.19 vs.22.43±5.23 ng/ml,P<0.001).whereas serum levels of CRP were higher in patients with VN than in controls(15.86±8.37 vs.ng/ml,P<0.001)Regression analyses demonstrated that vitamin D and CRP were associated with VN,with an odds ratio of 1.187(95%CI 1.046~1.093,P=0.001)and 1.223(95%CI=1.10~1.36,P=0.000).Conclusion VN is associated with evidence of an acute inflammatory response,we found that serum 25(OH)D and CRP may be associated with VN occurrence.

关 键 词：前庭神经炎 C反应蛋白 25羟维生素D 

分 类 号：R747.9[医药卫生—神经病学与精神病学]