肝细胞癌不完全热消融后肿瘤发展的研究进展  

Research progress of in tumor development after incomplete thermal ablation of hepatocellular carcinoma

作　　者：张文轩 尹训波[2] 孔健[1] 孙文兵[1] Zhang Wenxuan;Yin Xunbo;Kong Jian;Sun Wenbing(Department of Hepatobiliary-Pancreatic-Splenic Surgery,West Campus,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100043,China;Xintai People′s Hospital,Taian 271200,China)

机构地区：[1]首都医科大学附属北京朝阳医院肝胆胰脾外科,100043 [2]新泰市人民医院,泰安271200

出　　处：《中华实验外科杂志》2021年第10期2081-2084,共4页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金(81502650、81572957);北京市医院管理中心青年人才培养"青苗"计划(QML20190306);首都医科大学校自然科学基金(2019)。

摘　　要：射频消融(RFA)是肝细胞癌(HCC)潜在的治愈手段之一。HCC的病理特点、肿瘤的特殊位置及操作技术等原因导致RFA治疗HCC时未能达到病理性完全消融,进而产生肿瘤残留。残留癌侵袭、转移等能力增强是影响HCC远期疗效的重要因素。HCC RFA后残留癌进展的机制涉及炎症、上皮-间充质转化、肿瘤细胞干细胞特性增强、自噬、肿瘤微环境等。本文就HCC RFA后残留癌进展的机制及治疗策略进行综述,以期为提高HCC RFA疗效提供研究思路。Radiofrequency ablation(RFA)is one of the potential treatments for hepatocellular carcinoma(HCC).Pathological characteristics,special tumor location and surgical techniques of HCC may lead to failure of pathological complete ablation during RFA therapy for HCC,resulting in tumor residues.The enhanced ability of residual tumor invasion and metastasis is an important factor affecting the long-term efficacy of HCC.The mechanisms of residual tumor progression after RFA are involved in inflammation,epithelial mesenchymal transformation,enhancement of tumor stem cell characteristics,autophagy,and tumor microenvironment and so on.In this paper,the mechanisms and treatment strategies of residual tumor progression after insufficient RFA were reviewed in order to provide innovative ideas for improving the efficacy of HCC after RFA.

关 键 词：肝细胞癌 射频消融 残留癌 进展 

分 类 号：R735.7[医药卫生—肿瘤]