乙型病毒性肝炎相关肝内胆管癌致病机制研究进展  

Advances in study on pathogenesis of hepatitis B virus-associated intrahepatic cholangiocarcinoma

作　　者：赵帅[1] 王健 韩冰 张亦弛[1] 丁瀚 蔡浩 顾劲扬 Zhao Shuai;Wang Jian;Han Bing;Zhang Yichi;Ding Han;Cai Hao;Gu Jinyang(Department of Transplantation,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China)

机构地区：[1]上海交通大学医学院附属新华医院移植科,200092

出　　处：《中华实验外科杂志》2021年第10期2089-2092,共4页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金(82072646、81772507);促进市级医院临床技能与临床创新能力三年行动计划重大临床研究项目(SHDC2020CR3005A);上海市教委高峰高原人才计划(20191910);上海交通大学"医工交叉研究基金"(YG2021QN50)。

摘　　要：肝内胆管癌发病率仅次于肝细胞癌位列原发性肝癌第二位,近20年来在全球范围内特别东南亚国家呈倍增的态势。肝内胆管癌的致病因素主要包括肝内胆管结石、原发性硬化性胆管炎、肝吸虫病等,近年来乙型肝炎病毒感染亦被发现为肝内胆管癌发生的重要病因。本文就乙型病毒性肝炎相关肝内胆管癌潜在发病机制进行综述。The incidence of intrahepatic cholangiocarcinoma ranks secondly only to hepatocellular carcinoma as primary liver cancerwith a doubledincrease worldwide,especially in Southeast Asian countries over the past 20 years.The main pathogenic factors for intrahepatic cholangiocarcinoma include hepatolithiasis,primary sclerosing cholangitis,liver fluke disease,and so on.Recently,hepatitis B virus infection has been identified as important etiology of intrahepatic cholangiocarcinoma.This article provides a review of the potential pathogenesis of hepatitis B virus-associated intrahepatic cholangiocarcinoma.

关 键 词：肝内胆管癌 乙型肝炎病毒 血管新生 发病机制 人端粒酶反转录酶 

分 类 号：R735.8[医药卫生—肿瘤]