Herpesviruses and the TypeⅢInterferon System  

作　　者：Yue Yin Herman W.Favoreel 

机构地区：[1]Department of Virology,Parasitology and Immunology,Faculty of Veterinary Medicine,Ghent University,9820 Merelbeke,Belgium

出　　处：《Virologica Sinica》2021年第4期577-587,共11页中国病毒学（英文版）

基　　金：Research of YY and HWF is supported by grants from the Special Research Fund of Ghent University(CSC-cofunding grant and Concerted Research Action GOA013-17).

摘　　要：TypeⅢinterferons(IFNs)represent the most recently discovered group of IFNs.Together with typeⅠIFNs(e.g.IFN-α/β),typeⅢIFNs(IFN-λ)are produced as part of the innate immune response to virus infection,and elicit an anti-viral state by inducing expression of interferon stimulated genes(ISGs).It was initially thought that typeⅠIFNs and typeⅢIFNs perform largely redundant functions.However,it has become evident that typeⅢIFNs particularly play a major role in antiviral protection of mucosal epithelial barriers,thereby serving an important role in the first-line defense against virus infection and invasion at contact areas with the outside world,versus the generally more broad,potent and systemic antiviral effects of typeⅠIFNs.Herpesviruseses are large DNA viruses,which enter their host via mucosal surfaces and establish lifelong,latent infections.Despite the importance of mucosal epithelial cells in the pathogenesis of herpesviruses,our current knowledge on the interaction of herpesviruses with typeⅢIFN is limited and largely restricted to studies on the alphaherpesvirus herpes simplex virus(HSV).This review summarizes the current understanding about the role of IFN-λin the immune response against herpesvirus infections.

关 键 词：TypeⅢinterferon(IFN-λ) HERPESVIRUS Innate immunity Herpes simplex virus(HSV) 

分 类 号：S852.4[农业科学—基础兽医学]