伴基质分化的基底细胞癌1例  

A Case of Basal Cell Carcinoma with Matrical Differentiation

作　　者：张晓岚 杜宏宇 李东宁 杨静 ZHANG Xiaolan;DU Hongyu;LI Dongning;YANG Jing(Department of Dermatology,the First Affiliated Hospital of Jinzhou Medical University,Jinzhou 121001,China;Department of Pathology,the First Affiliated Hospital of Jinzhou Medical University,Jinzhou 121001,China)

机构地区：[1]锦州医科大学附属第一医院皮肤科,辽宁锦州121001 [2]锦州医科大学附属第一医院病理科,辽宁锦州121001

出　　处：《中国皮肤性病学杂志》2021年第10期1166-1169,共4页The Chinese Journal of Dermatovenereology

摘　　要：患者男,56岁,左侧胸部红斑2年,加重伴结节溃疡6个月。皮肤科情况:左侧胸部可见一10 cm×7 cm大小的暗红斑,中央一直径约为5 cm大小的结节,中央形成溃疡,部分表面结褐色痂皮。皮损组织病理示:表皮增生,部分溃疡形成,真皮内团块状基底样细胞和毛母质细胞增生,部分瘤细胞团与表皮相连,周边呈栅栏状改变,团块中间可见嗜酸性影细胞,间质胶原纤维增生。免疫组织化学示:基底状细胞区域EPCAM,Bcl-2,P40,CK7呈阳性,β-catenin在肿瘤细胞团周围及基质分化部位细胞膜及细胞浆呈阳性,Ki-67呈80%阳性。诊断:伴基质分化的基底细胞癌。A 56-year-old male presented with erythema on the left chest for two years,aggravated with nodular ulcer for 6 months.Dermatological examination showed a dark-red color and clear-border macule approximate 10 cm×7 cm in size was seen on the left chest.A 5 cm round mass with ulceration and exudates was detected within the erythema.Brown scab was on the surface of ulcer.Histopathological examination showed several focal ulcers were found within the epidermis and the infiltration of multiple tumor masses with various shapes were also observed in the dermis.Furthermore,the tumor mass was basically composed of basal cells and matrical component,while the central areas of the tumor are comprised of shadow-cell nests which is characterized by significant eosinophilia and center-localized unstained nuclei.Interstitial collagen fibers proliferated.In addition,the Immunohistochemical analysis demonstrated multiple positive reactions for EPCAM,Bcl-2,P40,and CK7 in the basal-cell carcinoma areas,β-Catenin was positive in cytoplasm around the tumor cell mass and matrical differentiation areas.Ki-67 was 80%.Diagnosis:basal cell carcinoma Matrical differentiation(BCC-MD).

关 键 词：基底细胞癌 基质分化 毛母质癌 手术 

分 类 号：R739.5[医药卫生—肿瘤]