PTTG、PAK2在膀胱癌组织中的表达及与临床分期、预后生存的相关性  

The expression of PTTG and PAK2 in bladder cancer tissues and their correlation with clinical staging and prognostic survival.

作　　者：汪小丽 蔡建红 李红波 WANG Xiao-li;CAI Jian-hong;LI Hong-bo(Department of Urology,Rugao Hospital Affiliated to Nantong University(Rugao People's Hospital),Rugao Jiangsu 226500,China.)

机构地区：[1]南通大学附属如皋医院(如皋市人民医院)泌尿外科,江苏如皋226500

出　　处：《临床和实验医学杂志》2021年第15期1639-1643,共5页Journal of Clinical and Experimental Medicine

基　　金：江苏省卫生计生委科研项目(编号:Z201525)。

摘　　要：目的探究垂体肿瘤转化基因(PTTG)、p21激活激酶(PAK)2在膀胱癌组织中表达及与临床分期、预后生存的相关性。方法回顾性选择2018年1月至2019年6月南通大学附属如皋医院收治的97例行手术治疗的膀胱癌患者,收集对应膀胱癌组织和癌旁正常上皮组织标本。采用免疫组化检测组织中PTTG、PAK2表达情况,并分析其与患者临床病理分期、预后的关系。结果膀胱癌组织中PTTG阳性表达率(78.35%)高于癌旁组织(10.31%),PAK2阳性表达率(55.67%)高于癌旁组织(12.37%),差异均有统计学意义(P<0.05)。TNM分期中T_(2)~T_(3)分期、高级别肿瘤、淋巴结转移、肿瘤直径≥3 cm患者PTTG、PAK2阳性表达率分别高于T_(is)~T_(1)期、低级别肿瘤、淋巴结未转移、肿瘤直径<3 cm患者,差异均有统计学意义(P<0.05)。Spearman等级相关性分析显示,PTTG与PAK2阳性表达呈正相关(r=0.388,P<0.001)。术后随访3~18个月,97例患者中有62例未出现复发或转移,其中PTTG阳性患者的无进展生存率(55.26%)低于阴性患者(95.24%),PAK2阳性患者的无进展生存率(40.74%)低于阴性患者(93.02%),差异均有统计学意义(P<0.05)。结论PTTG、PAK2在膀胱癌组织中表达升高,且与患者临床病理分期有关,可作为预后预测的潜在参考指标。Objective To explore the expression of pituitary tumor transforming gene(PTTG)and p21 activated kinase(PAK)2 in bladder cancer tissues and their correlation with clinical staging and prognostic survival.Methods Ninety-seven bladder cancer patients treated in Rugao Hospital Affiliated to Nantong University from January 2018 to June 2019 were retrospectively selected with their specimens of bladder cancer tissue and normal epithelial tissue adjacent to cancer being collected.The expression of PTTG and PAK2 in the tissues was detected using immunohistochemistry to analyze their relationship with the clinical pathological stage and prognosis of patients.Results The positive expression rate of PTTG in bladder cancer tissue(78.35%)was higher than that in adjacent tissues(10.31%),and the positive expression rate of PAK2(55.67%)was higher than that in adjacent tissues(12.37%),the differences were statistically significant(P<0.05).The positive expression rate of PTTG and PAK2 in patients with T_(2)-T_(3) stage in TNM staging,high-grade tumor,lymph node metastasis,and tumor diameter≥3 cm was higher than those with T_(is)-T_(1) stage,low-grade tumor,lymph node metastasis,and tumor diameter<3 cm,the differences were statistically significant(P<0.05).Spearman rank correlation analysis showed that PTTG was positively correlated with PAK2 positive expression(r=0.388,P<0.001).After 3-18 months of follow-up,62 of 97 patients did not relapse or had metastasis,while the progression-free survival rate of PTTG-positive patients(55.26%)was lower than that of negative patients(95.24%),and the progression-free survival rate of PAK2-positive patients(40.74%)was lower than that of negative patients(93.02%),the differences were statistically significant(P<0.05).Conclusion PTTG and PAK2 are elevated in bladder cancer tissues,which are related to the clinical pathological stage of patients and can be used as potential reference indicators for prognosis prediction.

关 键 词：膀胱癌 垂体肿瘤转化基因 p21激活激酶2 临床分期 预后 

分 类 号：R737.14[医药卫生—肿瘤]