淋巴细胞与单核细胞比值与食管鳞癌患者预后转归的关联  

Relationship between lymphocyte-monocyte ratio and prognosis in patients with esophageal squamous cell carcinoma.

作　　者：杨培[1] 蒋祥德[1] 程刚[1] 张华鹏[1] 陈方[1] 刘华[1] YANG Pei;JIANG Xiang-de;CHENG Gang(Department of Oncology,Bozhou People's Hospital,Bozhou Anhui 236800,China.)

机构地区：[1]亳州市人民医院肿瘤科,安徽亳州236800

出　　处：《临床和实验医学杂志》2021年第18期1990-1994,共5页Journal of Clinical and Experimental Medicine

基　　金：安徽省科技攻关计划项目(编号:1604a0802241)。

摘　　要：目的探究食管鳞癌患者淋巴细胞与单核细胞比值(LMR)与食管鳞癌患者预后转归之间的关联。方法回顾性选取2017年6月至2018年5月亳州市人民医院收治的77例确诊的食管鳞癌患者。检测患者的淋巴细胞和单核细胞数值,计算LMR值,根据患者LMR值将其分为LMR<3.66组(n=46)和LMR≥3.66组(n=31)。根据N-M分期,患者的分组包括N 0-N 1(n=34)、≥N 2(n=33)和≥M 1(n=10)3组。分析LMR与N-M分期的相关性;分析不同组别患者临床病理特征;分析LMR与食管鳞癌患者预后的相关性,单因素和多因素分析影响食管鳞癌患者预后的因素。结果2组患者不同N-M分期相比,差异有统计学意义(P<0.05)。N 0-N 1期的2组患者病变部位和浸润深度的差异均有统计学意义(P<0.05);≥N 2期的2组患者病变部位、病变长度、淋巴结转移和浸润深度的差异均有统计学意义(P<0.05)。2组1~2年生存率相比差异无统计学意义(P>0.05);LMR≥3.66组患者的3年的生存率显著高于LMR<3.66组的患者,差异有统计学意义(P<0.05)。通过单因素分析可知,年龄、病变部位、病变长度、N-M分期、临床分期、淋巴结转移和浸润深度也是食管鳞癌患者预后影响因素(P<0.05)。Logistic回归分析结果则显示,年龄、病变部位、N-M分期、淋巴结转移和LMR水平是影响食管鳞癌患者预后转归的独立预后因素(P<0.05)。结论LMR是食管鳞癌患者预后的关键指标,其中LMR≥3.66的患者预后效果较好。另外,年龄、病变部位、N-M分期、淋巴结转移和LMR水平是影响食管鳞癌患者预后转归的独立预后因素。Objective To explore the association between lymphocyte-monocyte ratio and prognosis in patients with esophageal squamous cell carcinoma.Methods A total of 77 patients with confirmed esophageal squamous cell carcinoma admitted to Bozhou People's Hospital from June 2017 to May 2018 were selected retrospectively.The patient's lymphocytes and monocytes were measured,and the lymphocyte to monocyte ratio(LMR)was calculated.According to the LMR value of patients,they were divided into two groups:LMR<3.66 group(n=46)and LMR≥3.66 group(n=31).According to the N-M staging,patients are divided into 3 groups:N 0-N 1(n=34),≥N 2(n=33)and≥M 1(n=10)group.The correlation between LMR and N-M staging was analyzed;The clinicopathological characteristics of patients in different groups were analyzed.The correlation between LMR and the prognosis of patients with esophageal squamous cell carcinoma was analyzed.The factors affecting the prognosis of patients with esophageal squamous cell carcinoma were analyzed by single factor and multivariate analysis.Results The difference between the two groups of patients with different N-M stages was statistically significant(P<0.05).The differences in lesion location and depth of invasion between the two groups of patients in N 0-N 1 stage were statistically significant(P<0.05);Differences in lesion location,lesion length,lymph node metastasis and depth of invasion between the two groups of patients with≥N 2 stage were statistically significant(P<0.05).There was no statistically significant difference in 1-2 year survival rates between the two groups(P>0.05);the 3-year survival rate of patients in the LMR≥3.66 group was significantly higher than that of the patients in the LMR<3.66 group(P<0.05).Univariate analysis showed that age,lesion site,lesion length,N-M stage,clinical stage,lymph node metastasis and invasion depth were also prognostic factors of esophageal squamous cell carcinoma(P<0.05).Logistic regression analysis showed that age,lesion site,N-M stage,lymph node metastasis and

关 键 词：食管鳞癌 淋巴细胞 单核细胞 预后 转归 

分 类 号：R735.1[医药卫生—肿瘤]