Computed tomography-identified phenotypes of small airway obstructions in chronic obstructive pulmonary disease  

作　　者：Tao Li Hao-Peng Zhou Zhi-Jun Zhou Li-Quan Guo Linfu Zhou 

机构地区：[1]Department of Respiratory and Critical Care Medicine,The First Affiliated Hospital,Nanjing Medical University,Nanjing,Jiangsu 210029,China [2]Department of Respiratory Medicine,Xuzhou First People’s Hospital,Xuzhou,Jiangsu 221116,China [3]Department of Medicine,Jiangsu University School of Medicine,Zhenjiang,Jiangsu 212013,China [4]Institute of Radio Frequency&Optical Electronics-Integrated Circuits,School of Information and Engineering,Southeast University,Nanjing,Jiangsu 210096,China [5]Suzhou Institute of Biomedical Engineering and Technology,Chinese Academy of Sciences,Suzhou,Jiangsu 215163,China [6]Institute of Integrative Medicine,Nanjing Medical University,Nanjing,Jiangsu 210029,China

出　　处：《Chinese Medical Journal》2021年第17期2025-2036,共12页中华医学杂志（英文版）

基　　金：This work was supported by the grants from the National Key Research and Development Program of China(No.2018YFC1313602);Major International(Regional)Joint Research Project(No.81820108001);National Natural Science Foundation of China(No.81670029);Jiangsu Key Principal Investigator of Medicine(No.ZDRCA2016018);Project 333 for Cultivation of Young and Middle-aged Leading Talents(No.BRA2019078);Jiangsu Key Program of Social Development(No.BE2015651);Nanjing Key Project of Science and Technology(No.2019060002)(to L.Zhou);Xuzhou Administration of Science and Technology(No.KC20082).

摘　　要：Chronic obstructive pulmonary disease(COPD)is a heterogeneous disease characteristic of small airway inflammation,obstruction,and emphysema.It is well known that spirometry alone cannot differentiate each separate component.Computed tomography(CT)is widely used to determine the extent of emphysema and small airway involvement in COPD.Compared with the pulmonary function test,small airway CT phenotypes can accurately reflect disease severity in patients with COPD,which is conducive to improving the prognosis of this disease.CT measurement of central airway morphology has been applied in clinical,epidemiologic,and genetic investigations as an inference of the presence and severity of small airway disease.This review will focus on presenting the current knowledge and methodologies in chest CT that aid in identifying discrete COPD phenotypes.

关 键 词：Chronic obstructive pulmonary disease Small airway obstruction Computed tomography PHENOTYPE Pulmonary function test 

分 类 号：R563.9[医药卫生—呼吸系统] R816.4[医药卫生—内科学]