大豆粉对围绝经期患者血清E2、FSH和LH激素水平的影响及症状的改善研究  

Effects of soybean powder on serum E2,FSH and LH hormone levels and symptom improvement in perimenopausal patients

作　　者：黄华勇[1] 叶艳彬[2] 叶育芳[1] 罗小婉[1] 匡晓梅[1] HUANG Huayong;YE Yanbin;YE Yufang;LUO Xiaowan;KUANG Xiaomei(Department of Women Health Care,Bo′ai Hospital of Zhongshan,Zhongshan,Guangdong 528400,China;Department of Clinical Nutrition,the First Affiliated Hospital of Sun Yat-Sen University,Guangzhou,Guangdong 510060,China)

机构地区：[1]广东省中山市博爱医院妇女保健科,广东中山528400 [2]中山大学附属第一医院临床营养科,广东广州510060

出　　处：《国际检验医学杂志》2021年第20期2491-2495,共5页International Journal of Laboratory Medicine

基　　金：广东省中山市重大青年培养基金项目(2016B1008)。

摘　　要：目的探讨日摄入50 g大豆粉对围绝经期患者血清雌二醇(E2)、促卵泡生成激素(FSH)和促黄体生成激素(LH)水平的影响及对症状的改善,为围绝经期综合征患者提供一种新的治疗方案。方法收集2016年2月至2019年12月期间,于中山市博爱医院妇女保健科就诊的298例围绝经期综合征患者为研究对象,在获得患者的知情并同意的情况下,分为4组:0 g组(无临床干预)72例、50 g组(日摄入50 g大豆粉)76例、75 g组(日摄入75 g大豆粉)74例和激素组(日口服克龄蒙1片)76例。对所有受试者进行为期6个月的随访跟踪和问卷调查。并进行E2、FSH和LH水平检测。结果(1)4组患者血清E2、FSH和LH激素水平变化之间的总体差异无统计学意义(P>0.05)。4组患者的围绝经期症状变化除眩晕外其他指标的变化之间差异均有统计学意义(P<0.05)。(2)50 g组患者的围绝经期症状变化除眩晕外其他指标与0 g组之间差异均有统计学意义(P<0.05),而与75 g组、激素组之间差异均无统计学意义(P>0.05)。(3)4组患者的前匹兹堡睡眠质量指数量表(PSQI)评分之间总体差异无统计学意义(P>0.05)。50 g组、75 g组与激素组之间的后PSQI评分、PSQI评分差的差异均无统计学意义(P>0.05),而50 g组、75 g组、激素组与0 g组的后PSQI评分、PSQI评分差之间的差异均有统计学意义(P<0.001)。(4)0 g组的前PSQI评分与后PSQI评分之间的差异无统计学意义(P>0.05),而50 g组、75 g组与激素组的前PSQI评分与后PSQI评分之间的差异均有统计学意义(P<0.05)。结论日摄入50 g大豆粉患者的E2、FSH和LH激素水平,与激素组患者相比差异无统计学意义,也能有效改善围绝经期症状(除眩晕),有潜能成为围绝经期综合征患者的一种新的治疗方案。Objective To investigate the effects of daily intake of 50 g soybean powder on the changes of serum estradiol(E2),follicle stimulating hormone(FSH)and luteinizing hormone(LH)levels and the improvement of symptoms in perimenopausal patients,so as to provide a new treatment for perimenopausal syndrome.Methods A total of 298 patients with perimenopausal syndrome in the Department of Gynecology,Zhongshan Bo′ai Hospital from February 2016 to December 2019 were selected as the research objects.With the patient′s informed consent,they were divided into 4 groups:72 cases in 0 g group(without clinical intervention),76 cases in 50 g group(daily intake of 50 g soybean powder),74 cases in 75 g group(daily intake of 75 g soybean powder)and 76 cases in hormone group(daily oral administration of kelinmeng one tablet).All subjects were followed up and investigated by questionnaire for 6 months.E2,FSH and LH levels were detected.Results There was no significant difference in serum E2,FSH and LH levels among the four groups(all P>0.05).There were significant differences in perimenopausal symptoms except vertigo among the four groups(all P<0.05).Except vertigo,there were significant differences in other indicators of perimenopausal symptoms between 50 g group and 0 g group(all P<0.05).There was no significant difference between 75 g group and hormone group(P>0.05).There was no significant difference in the pre Pittsburgh Sleep Quality Index(PSQI)scores among the four groups(P>0.05).There were no significant differences in post PSQI score and PSQI score difference among the 50 g group,75 g group and hormone group(P>0.05).There were statistically significant differences in post PSQI score and PSQI score difference between 50 g group,75 g group,hormone group and 0 g group(all P<0.001).There was no significant difference between pre PSQI score and post PSQI score in 0 g group(P>0.05).There were significant differences between the pre PSQI score and post PSQI score in the 50 g group,75 g group and hormone group(all P<0.05).Conclusio

关 键 词：大豆粉 围绝经期症状 症状 

分 类 号：R711.75[医药卫生—妇产科学]