智能化精准光学诊疗技术研究进展  

Research Progress in Intelligent and Precise Optical Diagnosis and Treatment Technology

作　　者：李阳曦 胡成全 马龙飞[1] 张欣然[1] 廖洪恩[1] Li Yangxi;Hu Chengquan;Ma Longfei;Zhang Xinran;Liao Hongen(Department of Biomedical Engineering,School of Medicine,Tsinghua University,Beijing 100084,China)

机构地区：[1]清华大学医学院生物医学工程系,北京100084

出　　处：《中国激光》2021年第15期289-309,共21页Chinese Journal of Lasers

基　　金：国家自然科学基金(82027807,81771940,81901844);北京市自然科学基金(7212202,L192013)。

摘　　要：现代光学成像和光学治疗技术的发展,为智能化精准微创诊疗平台的构建提供了重要的结构支撑。传统的诊断和治疗技术存在诊断与治疗过程相对独立,术前、术中信息不匹配,病灶信息模态单一,较为依赖医生经验等问题。近年来,结合计算机视觉、精密机械制造、自动化控制、纳米材料等手段,光学诊疗技术朝着智能化、精准化方向发展,促进临床手术系统走向诊疗一体化。本文从光学成像及智能化诊断方法、精准的光学治疗手段、光学诊疗仪器与一体化方法三个方面,对智能化精准光学诊疗技术研究进展进行综述。Significance With the growing demand for health care and the development of medical examinations,more accurate and minimally invasive diagnosis and treatment technologies have received extensive global attention.Currently,a rapid and effective intraoperative diagnostic method is still lacking for major diseases in clinical practice.Traditional medical imaging modalities,such as magnetic resonance imaging,computed tomography,ultrasound imaging,positron emission tomography,and single-photon emission computed tomography,are commonly used to present the global anatomical structure or functional information of human tissue,but their resolution is too low to show fine structures.Histopathological examination is the gold standard for malignant tumors and other diseases,which detect pathological changes in cells on a microscopic scale with the best accuracy.However,the process is complex and time-consuming and depends on the distribution of biopsy samples;therefore,it cannot cover a wide range of tissues.In addition,diagnosis and treatment procedures are relatively independent,leading to the mismatch of preoperative and intraoperative information,and surgical operations largely depend on the personal experience of surgeons. Represented by emerging optical imaging and spectroscopic methods,biomedical images at mesoscopic and macroscopic levels provide a good foundation for multimodal rapid and precise diagnosis,such as optical coherence tomography,two-photon microscopy,photoacoustic imaging,Raman spectroscopy and microscopic imaging,and fluorescence spectroscopy and imaging.Because of their excellent real-time performance,high accuracy,and resolution in intraoperative use,many of these methods are known as "optical biopsy".In terms of treatment,optical methods with high spatio-temporal selectivity,such as laser ablation,photodynamic therapy,and photothermal therapy have gradually entered clinical practice.At the same time,the development of computer vision,precision instruments,automation,and other research fields has pro

关 键 词：生物光学 光学诊断 光学治疗 诊疗一体化 微创诊疗 

分 类 号：TH773[机械工程—仪器科学与技术]