微创碎吸引流联合高压氧治疗对高血压脑出血患者炎性因子及脑血管动力学的影响  

Effects of minimally invasive aspiration and drainage combined with hyperbaric oxygen therapy on inflammatory factors and cerebrovascular dynamic indicators in patients with hypertensive intracerebral hemorrhage

作　　者：刘亚峰 王一芳 王青 于成 夏世翠 马虎龙 徐梦奇 Liu Yafeng;Wang Yifang;Wang Qing;Yu Cheng;Xia Shicui;Ma Hulong;Xu Mengqi(Department of Neurology,Nanjing Zijin Hospital,Nanjing 211100,China)

机构地区：[1]南京紫金医院,南京211100

出　　处：《中华航海医学与高气压医学杂志》2021年第4期437-441,共5页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

摘　　要：目的探讨微创碎吸引流联合高压氧治疗对高血压脑出血患者炎性因子及脑血管动力学的影响。方法选取2019年1月至2021年1月在四五四医院和南京紫金医院治疗的高血压脑出血患者74例,采用抽签法随机分为治疗组(微创碎吸引流联合高压氧治疗)和对照组(微创碎吸引流治疗)各37例。比较2组患者的血清炎性因子、脑血管动力学、动脉血气水平及神经功能评分。结果 2组患者治疗前血清炎性因子、脑血管动力学、动脉血气水平及神经功能评分差异无统计学意义(P>0.05);治疗30 d后,治疗组肿瘤坏死因子(TNF-α)、白细胞介素-1(IL-1)、IL-8等炎性因子水平低于对照组,美国国立卫生研究院卒中量表(NIHSS)评分、外周阻力(PR)、动态阻力(DR)低于对照组,简明智力状态检查(MMSE)评分、平均血流速度(Vm)、平均流量(Qm)、动脉血二氧化碳分压(PaCO2)、动脉血氧分压(PaO2)、酸碱度(pH)高于对照组,差异均有统计学意义(P<0.05)。结论微创碎吸引流联合高压氧治疗可有效缓解高血压脑出血患者的炎性反应,促进脑血管动力学指标及神经功能恢复。Objective To investigate the effects of minimally invasive aspiration and drainage combined with hyperbaric oxygen(HBO)therapy on inflammatory factors and cerebrovascular dynamic indicators in patients with hypertensive intracerebral hemorrhage.Methods A total of 74 patients with hypertensive intracerebral hemorrhage treated in 454 Hospital and Nanjing Zijin Hospital from January 2019 to January 2021 were selected and randomly divided into treatment group(n=37)given minimally invasive aspiration and drainage combined with HBO therapy and control group(n=37)given minimally invasive aspiration and drainage only.The levels of serum inflammatory factors,cerebrovascular dynamic indicators,arterial blood gas(ABG)levels,and the neurologic function scores in the two groups before and after treatment were compared.Results Before treatment,there was no significant difference between the two groups in the levels of serum inflammatory factors,cerebrovascular dynamic indicators,ABG levels,and the neurological function scores(P>0.05);after 30 days of treatment,the levels of inflammatory factors such as tumor necrosis factor-α(TNF-α),interleukin-1(IL-1),and IL-8 in the treatment group were lower than those in the control group,the National Institute of Health Stroke Scale(NIHSS)scores,the values of peripheral resistance(PR)and dynamic resistance(DR)in the treatment group were lower than those in the control group,while the Mini-mental State Examination(MMSE)scores,the mean blood flow velocities(Vm),mean blood flow quantities(Qm),the arterial partial pressures of CO2(PaCO2)and the arterial partial pressures of oxygen(PaO2),and the blood pH values in the treatment group were higher than those in the control group(P<0.05),and all the differences were statistically significant(P<0.05).Conclusion Minimally invasive aspiration and drainage combined with HBO therapy in the treatment of hypertensive intracerebral hemorrhage can effectively reduce the patients’inflammatory response and promote the recovery of cerebral vascular dynam

关 键 词：微创碎吸 高压氧 高血压脑出血 炎性因子 脑血管动力学 

分 类 号：R743.34[医药卫生—神经病学与精神病学] R459.6[医药卫生—临床医学]