乳果糖联合恩替卡韦治疗乙型肝炎后肝硬化的效果及对自发性腹膜炎发生率的影响  

Effect of lactulose combined with entecavir in the treatment of posthepatitic cirrhosis and its influence on the incidence of spontaneous peritonitis

作　　者：林国秋 赵蔚 LIN Guoqiu;ZHAO Wei(the Fifth People's Hospital of Longgang District,Shenzhen 518111;Longgang District Central Hospital of Shenzhen,Shenzhen 518116,China)

机构地区：[1]深圳市龙岗区第五人民医院,广东深圳518111 [2]深圳市龙岗中心医院,广东深圳518116

出　　处：《临床医学研究与实践》2021年第29期92-94,共3页Clinical Research and Practice

摘　　要：目的探讨乳果糖联合恩替卡韦治疗乙型肝炎后肝硬化的效果及对自发性腹膜炎发生率的影响。方法回顾性选取2016年10月至2020年10月本院120例乙型肝炎后肝硬化患者作为研究对象,依据治疗方法将其分为单独恩替卡韦治疗组(单独治疗组)和乳果糖联合恩替卡韦治疗组(联合治疗组),每组60例。比较两组患者的血清HBV-DNA水平、肝功能Child-Pugh评分、肝功能、临床疗效、HBV-DNA转阴、自发性腹膜炎及不良反应发生情况。结果治疗后,两组的HBV-DNA水平、肝功能Child-Pugh评分、ALT、AST、TBIL水平均降低,且联合治疗组低于单独治疗组(P<0.05)。联合治疗组的治疗总有效率为90.00%,显著高于单独治疗组的73.33%(P<0.05)。联合治疗组的自发性腹膜炎发生率为3.33%,显著低于单独治疗组的16.67%(P<0.05)。两组的不良反应总发生率无显著差异(P>0.05)。结论相较于单独应用恩替卡韦,乳果糖联合恩替卡韦治疗乙型肝炎后肝硬化效果显著,更能有效降低患者的自发性腹膜炎发生率。Objective To investigate the effect of lactulose combined with entecavir in the treatment of posthepatitic cirrhosis and its influence on the incidence of spontaneous peritonitis.Methods A total of 120 patients with posthepatitic cirrhosis in our hospital from October 2016 to October 2020 were retrospectively selected as the study objects.According to the treatment methods,the patients were divided into single entecavir treatment group(single treatment group)and lactulose combined with entecavir treatment group(combined treatment group),with 60 cases in each group.The serum HBV-DNA level,Child-Pugh score of liver function,liver function,clinical efficacy,the occurrence of negative HBV-DNA conversion,spontaneous peritonitis and adverse reactions were compared between the two groups.Results After treatment,the HBV-DNA level,Child-Pugh score of liver function,ALT,AST and TBIL levels in both groups decreased,and those in the combined treatment group were lower than the single treatment group(P<0.05).The total effective rate of treatment in the combined treatment group was 90.00%,which was significantly higher than 73.33%in the single treatment group(P<0.05).The incidence of spontaneous peritonitis in the combined treatment group was 3.33%,which was significantly lower than 16.67%in the single treatment group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Compared with entecavir alone,lactulose combined with entecavir has a significant effect in the treatment of posthepatitic cirrhosis,which can effectively reduce the incidence of spontaneous peritonitis of patients.

关 键 词：乙型肝炎后肝硬化 乳果糖 恩替卡韦 肝功能 自发性腹膜炎 血清HBV-DNA 

分 类 号：R575.29[医药卫生—消化系统]