Skeleton-vasculature chain reaction: a novel insight into the mystery of homeostasis  

作　　者：Ming Chen Yi Li Xiang Huang Ya Gu Shang Li Pengbin Yin Licheng Zhang Peifu Tang 

机构地区：[1]Department of Orthopedics,Chinese PLA General Hospital,Beijing,China [2]National Clinical Research Center for Orthopedics,Sports Medicine&Rehabilitation,Beijing,China

出　　处：《Bone Research》2021年第3期264-283,共20页骨研究（英文版）

基　　金：funded by the National Natural Science Foundation of China(81972102,81772369,81972115,82002330 and 81702176).

摘　　要：Angiogenesis and osteogenesis are coupled.However,the cellular and molecular regulation of these processes remains to be further investigated.Both tissues have recently been recognized as endocrine organs,which has stimulated research interest in the screening and functional identification of novel paracrine factors from both tissues.This review aims to elaborate on the novelty and significance of endocrine regulatory loops between bone and the vasculature.In addition,research progress related to the bone vasculature,vessel-related skeletal diseases,pathological conditions,and angiogenesis-targeted therapeutic strategies are also summarized.With respect to future perspectives,new techniques such as single-cell sequencing,which can be used to show the cellular diversity and plasticity of both tissues,are facilitating progress in this field.Moreover,extracellular vesicle-mediated nuclear acid communication deserves further investigation.In conclusion,a deeper understanding of the cellular and molecular regulation of angiogenesis and osteogenesis coupling may offer an opportunity to identify new therapeutic targets.

关 键 词：HOMEOSTASIS ORGANS diseases 

分 类 号：R33[医药卫生—人体生理学]