Bilobalide的全合成  

Full Synthesis of Bilobalide

作　　者：郭文改 顾凡 GUO Gaiwen;GU Fan(Wenzhou University,Wenzhou 325000,China)

机构地区：[1]温州大学,浙江温州325000

出　　处：《化工技术与开发》2021年第10期44-46,24,共4页Technology & Development of Chemical Industry

摘　　要：Bilobalide是从银杏叶中提取的一种倍半萜的内酯化合物,是一种神经系统、精神类的药物,对治疗因年老而出现的呆傻有较好的效果。它是一种五元环类物质,含有3个五元内酯和1个大位阻的叔丁基。合成这种超级拥挤的立体结构且含有大位阻的不稳定物质,对研究者来说是一项巨大的挑战。为了更好地推近Bilobalide全合成的研究,本文对已报道的天然产物Bilobalide全合成的相关工作进行了总结,详细阐述了整个合成过程。Bilobalide,a sesquiterpene lactone compound extracted from ginkgo bilobalide leaves,was a neurological and psychiatric drug that had a better effect on the dullness of aging.It was a five-membered ring containing three five-membered lactones and a large steric hindrance tert-butyl group.The synthesis of this super crowded three-dimensional structure with large steric hindrance,was a huge challenge for the synthesizer.In order to better promote the development of bilobalide’s full synthesis,this paper summarized the work related to the full synthesis of bilobalide,a reported natural product,and elaborated the whole synthesis process.

关 键 词：BILOBALIDE 全合成 银杏叶 

分 类 号：R962[医药卫生—药理学]