BILOBALIDE

作品数：14被引量：25H指数：3
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相关领域：医药卫生更多>>
相关作者：宋伟周利军郑世曦张丽韦萍更多>>
相关机构：中国科学院华中农业大学华中科技大学南京工业大学更多>>
相关期刊：《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》《化工技术与开发》《Neural Regeneration Research》更多>>
相关基金：国家自然科学基金天津市自然科学基金国家科技支撑计划更多>>
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Bioactivity and Molecular Mechanism of Bilobalide
《Asian Agricultural Research》2025年第2期34-37,共4页Junhao LI Xichun HUANG Quan QUAN Mingxinzhi WANG Jingchao WANG Chenghao JIN 
Supported by Heilongjiang Provincial Key Research and Development Plan Guidance Project(GZ20220039);Central Government Supports Local College Reform and Development Fund Talent Training Projects(2020GSP16).
Ginkgo biloba is a deciduous tree belonging to Ginkgo,Ginkgoaceae.It is often used to treat dizziness,tinnitus,vertigo,hyperlipidemia and diabetic peripheral neuropathy.Bilobalide is a natural active compound derived ...
关键词：BILOBALIDE ANTI-INFLAMMATORY Obesity treatment NEUROPROTECTION HEPATOPROTECTION 
Impaired tricarboxylic acid cycle flux and mitochondrial aerobic respiration during isoproterenol induced myocardial ischemia is rescued by bilobalide被引量：5
《Journal of Pharmaceutical Analysis》2021年第6期764-775,共12页Zhe Wang Fan Zhang Wei Liu Ning Sheng Hua Sun Jinlan Zhang 
supported by grants from the National Natural Science Foundation of China(Grant No.:81803496);the CAMS Innovation Fund for Medical Sciences(Grant No.:2016-I2M-3-016);the Applications and Core Technology University Research(ACT-UR,Grant No.:4084)。
There is an urgent need to elucidate the pathogenesis of myocardial ischemia(MI)and potential drug treatments.Here,the anti-MI mechanism and material basis of Ginkgo biloba L.extract(GBE)were studied from the perspect...
关键词：BILOBALIDE Isoproterenol-induced myocardial ischemia Tricarboxylic acid cycle Stable isotopic tracing metabolic flux analysis Seahorse test 
Bilobalide的全合成
《化工技术与开发》2021年第10期44-46,24,共4页郭文改 顾凡 
Bilobalide是从银杏叶中提取的一种倍半萜的内酯化合物,是一种神经系统、精神类的药物,对治疗因年老而出现的呆傻有较好的效果。它是一种五元环类物质,含有3个五元内酯和1个大位阻的叔丁基。合成这种超级拥挤的立体结构且含有大位阻的...
关键词：BILOBALIDE 全合成 银杏叶 
An UHPLC-MS/MS method for simultaneous determination of quercetin 3-O-rutinoside, kaempferol 3-O-rutinoside, isorhamnetin 3-O-rutinoside, bilobalide and ligustrazine in rat plasma, and its application to pharmacokinetic study of Xingxiong injection被引量：6
《Chinese Journal of Natural Medicines》2017年第9期710-720,共11页DOU Li-Li DUAN Li GUO Long LIU Le-Le ZHANG Yu-Dong LI Ping LIU E-Hu 
financially supported from National Natural Science Foundation of China(Nos.81673569,and 81473343);Program for New Century Excellent Talents in University(No.NECT-13-1034);a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions
The present study was designed to develop and validate a rapid, sensitive, and reliable ultra-high performance liquid chromatography coupled with tandem mass spectrometry(UHPLC-MS/MS) method for the simultaneous deter...
关键词：UHPLC-MS/MS Xingxiong injection Pharmacokinetics Rat plasma 
Inhibitory effects of phytochemicals on metabolic capabilities of.CYP2D6＊1 and CYP2D6＊10 using cell-based models in vitro
《Acta Pharmacologica Sinica》2014年第5期685-696,共12页Qiang QU Jian QU Lu HAN Min ZHAN Lan-xiang WU Yi-wen ZHANG Wei ZHANG Hong-hao ZHOU 
This work was supported by the State Scholarship Fund from China Scholarship Council （No 201206370103）, the National Natural Science Foundation of China （No 81273595, 81072706, and 84402511）, the Scientific Foundation of Hunan （No 11K073 and 10JJ4020）, the ＂863＂ Project （No 2012AA02A518）, NCET- 10-0843 and the Research Innovation Foundation of Graduate Student in Hunan province, China （CX2011B056）. We are grateful to Dr Curtis D KLAASSEN and Helen RENAUD who provided language help.
Aim： Herbal products have been widely used, and the safety of herb-drug interactions has aroused intensive concerns. This study aimed to investigate the effects of phytochemicals on the catalytic activities of human ...
关键词：CYP2D6 drug interaction herbal medicine COPTISINE BILOBALIDE schizandrin LUTEOLIN PUERARIN 
Bilobalide inhibits the expression of aquaporin 1, 4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia
《Neural Regeneration Research》2011年第27期2105-2111,共7页Haiming Qin Fulin Song Hongguang Han Hong Ou Xingwen Zhai Bin Qin Song You 
a Research Subject of General Hospital of Shenyang Military Area Command of Chinese PLA
The present results demonstrated that in an adult rat model of permanent middle cerebral artery occlusion （pMCAO）, pretreatment with bilobalide reduced brain water content and infarct area, down-regulated aquaporin ...
关键词：bilobalide aquaporin brain edema permanent middle cerebral artery occlusion glial fibrillary acidic protein neural regeneration 
The mixture of procyanidins extracted from the lotus seed pod and bilobalide ameliorates scopolamine-induced memory impairment in mice被引量：1
《Neuroscience Bulletin》2009年第4期203-208,共6页张丽 许继取 荣爽 谢笔钧 孙智达 张允建 刘烈刚 
supported by the National Key Technology R&D Program of China (No.2006BAD27B08 and 2006BAD27B09-4)
Objective To study the co-effect of procyanidins extracted from the lotus seed pod （LSPC） and bilobalide （BIL） on ameliorating scopolamine-induced learning and memory impairment in young mice. Methods Fifty male K...
关键词：lotus seed pod procyanidins BILOBALIDE SCOPOLAMINE MICE learning and memory 
Bilobalide inhibits 6-OHDA-induced activation of NF-κB and loss of dopaminergic neurons in rat substantia nigra被引量：8
《Acta Pharmacologica Sinica》2008年第5期539-547,共9页Ling-yun LI Xi-lin ZHAO Xi-feng FEI Zhen-lun GU Zheng-hong QIN Zhong-qin LIANG 
Iproject supported by grants from the National Natural Science Foundation of China （No 30672452）, the Natural Science Foundation of Jiangsu Province （No BK2006051）, and the Natural Science Foundation of Jiangsu High Education Bureau （No 05KJB310117）.
Aim： To investigate the effects of bilobalide on the activation of NF-κB, and apoptosis of dopaminergic neurons induced by 6-hydroxydopamine （6-OHDA）. Methods： A rat model of Parkinson＇ s disease was produced wi...
关键词：BILOBALIDE 6-HYDROXYDOPAMINE Parkinson＇sdisease NF-ΚB apoptosis 
Effect of bilobalide B on cholinergic hippocampal neurons exposed to cholesterol and apolipoprotein E4被引量：1
《Neural Regeneration Research》2008年第5期469-471,共3页Xijuan Jiang Bin Lu Yingchang Fan 
the Natural Science Foundation of Tianjin Educational Bureau, No.20030117
BACKGROUND： Extracts of ginkgo biloba leaves have been reported to improve nerve function and activity in Alzheimer＇s disease, which is associated with reduced secretion of cholinergic neurotransmitter in hippocampa...
关键词：Alzheimer＇s disease CHOLESTEROL apolipoprotein E4 bilobalide B ACETYLCHOLINE ACETYLCHOLINESTERASE choline acetyltransferase 
High Performance Liquid Chromatography-Electrospray Ionization-Mass Spectrometric Analysis of Bilobalide and Ginkgolides in Ginkgo biloba L. Leaves被引量：1
《Journal of Chinese Pharmaceutical Sciences》2002年第2期26-30,共5页卢定强 韦萍 欧阳平凯 陈钧 
The ginkgo terpenoids including bilobalide and ginkgolides are the main pharmaceutical components in the leaves or extracts of Ginkgo biloba L. In this paper, the analysis of bilobalide and ginkgolides in leaves of Gi...
关键词：High performance liquid chromatography Electrospray ionization Mass spectrometry Ginkgo terpene lactones 
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