Bioactivity and Molecular Mechanism of Bilobalide  

作　　者：Junhao LI Xichun HUANG Quan QUAN Mingxinzhi WANG Jingchao WANG Chenghao JIN 

机构地区：[1]College of Life Science and Biotechnology,Heilongjiang Bayi Agricultural University,Daqing 163319,China

出　　处：《Asian Agricultural Research》2025年第2期34-37,共4页亚洲农业研究(英文)

基　　金：Supported by Heilongjiang Provincial Key Research and Development Plan Guidance Project(GZ20220039);Central Government Supports Local College Reform and Development Fund Talent Training Projects(2020GSP16).

摘　　要：Ginkgo biloba is a deciduous tree belonging to Ginkgo,Ginkgoaceae.It is often used to treat dizziness,tinnitus,vertigo,hyperlipidemia and diabetic peripheral neuropathy.Bilobalide is a natural active compound derived from the leaves and fruits of G.biloba,which exhibits a range of pharmacological effects,including anti-inflammatory properties,obesity treatment,neuroprotection,and hepatoprotection.This paper provides a comprehensive review of the pharmacological actions and molecular mechanisms of bilobalide,with a particular focus on its roles in anti-inflammatory responses,metabolic regulation,neuroprotection,and hepatoprotection.Research has demonstrated that bilobalide exerts its pharmacological effects through the regulation of various signaling pathways,including AMPK/SIRT1/mTOR,STAT3,and Nrf-2/HO-1.This paper aims to establish a theoretical foundation for the further investigation,development,and application of bilobalide.

关 键 词：BILOBALIDE ANTI-INFLAMMATORY Obesity treatment NEUROPROTECTION HEPATOPROTECTION 

分 类 号：R285[医药卫生—中药学]