胃癌组织中溶酶体相关四次跨膜蛋白B、三叶因子家族1表达与胃癌的关系  

The relationship between the expression of LAPTM4B and TFF1 and tumor in gastric cancer

作　　者：宋铁英[1] 李莹莹[1] 郭娟[1] SONG Tieying;LI Yingying;GUO Juan(Department of Laboratory Division,Zhengzhou People's Hospital,Zhengzhou,Henan 450000,China)

机构地区：[1]郑州人民医院检验科,河南郑州450000

出　　处：《安徽医药》2021年第11期2219-2222,I0003,共5页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨胃癌组织中溶酶体相关四次跨膜蛋白B(LAPTM4B)、三叶因子家族1(TFF1)蛋白表达与胃癌的关系。方法选取2015年8月至2018年6月郑州人民医院收集的80例胃癌组织及40例胃癌癌旁组织,采用免疫组织化学染色技术检测LAPTM4B、TFF1蛋白表达情况,观察不同病灶最大径、TNM分期、组织学分化程度、淋巴结转移情况、浸润程度及胃癌组织中LAPTM4B、TFF1蛋白的阳性表达率。结果胃癌组织中LAPTM4B蛋白阳性表达率为61.25%、TFF1蛋白阳性表达率为68.75%,胃癌癌旁组织中LAPTM4B蛋白阳性表达率为25.00%、TFF1蛋白阳性表达率为35.00%;胃癌组织均高于癌旁组织(P<0.05)。在TNM分期(Ⅲ期+Ⅳ期)、发生淋巴结转移的胃癌组织中LAPTM4B蛋白阳性表达率分别为78.79%、74.42%,高于TNM分期(Ⅰ期+Ⅱ期)48.94%、未发生淋巴结转移45.95%的病人(P<0.05);在TNM分期(Ⅲ期+Ⅳ期)、发生淋巴结转移、低分化的胃癌组织中TFF1蛋白阳性表达率分别为90.91%、81.40%、87.10%,高于TNM分期(Ⅰ期+Ⅱ期)53.19%、未发生淋巴结转移54.05%、高分化和中分化的57.14%,差异有统计学意义(P<0.05)。结论胃癌组织中LAPTM4B、TFF1表达强度明显较癌旁组织增强,可能与胃癌的发生及发展有一定的关系。Objective To investigate the relationship between lysosomal-associated 4th transmembrane protein B(LAPTM4B)and trefoil factor family 1(TFF1)protein expression and gastric cancer.Methods Eighty gastric cancer tissues and 40 gastric cancer tissues collected from the Zhengzhou People's Hospital from August 2015 to June 2018 were selected.The expression of LAPTM4B and TFF1 protein was detected by immunohistochemical staining.The differences in the expression rates of LAPTM4B and TFF1 proteins in gas‐tric cancer tissues with different lesion diameter,TNM stage,histological differentiation,lymph node metastasis and infiltration were ana‐lyzed.Results The positive expression rate of LAPTM4B protein and TFF1 protein in gastric cancer tissues was 61.25%and 68.75%,respectively.The positive expression rate of LAPTM4B protein and TFF1 protein in paracancerous tissues was 25.00%and 35.00%,re‐spectively(P<0.05).The positive expression rates of LAPTM4B protein in gastric cancer tissues with TNM stage(stageⅢ+Ⅳ)and lymph node metastasis were 78.79%and 74.42%,respectively,which were higher than 48.94%in patients with TNM stage(stageⅠ+Ⅱ)and 45.95%in patients without lymph node metastasis(P<0.05);The positive expression rates of TFF1 protein in TNM stage(stageⅢ+Ⅳ),lymph node metastasis,and poorly differentiated gastric cancer were 90.91%,81.40%,and 87.10%,respectively,which was higher than 53.19%in TNM stage(stageⅠ+Ⅱ),54.05%without lymph node metastasis and 57.14%in well-differentiated and moderately dif‐ferentiated gastric cancer tissues(P<0.05).Conclusion The expression intensity of LAPTM4B and TFF1 in gastric cancer tissues is sig‐nificantly higher than that in adjacent tissues,which may be related to the occurrence and development of gastric cancer.

关 键 词：胃肿瘤 溶酶体相关四次跨膜蛋白(LAPTM4B) 三叶因子家族1 

分 类 号：R735.2[医药卫生—肿瘤]