颈动脉血管重建术对眼缺血综合征病人血流动力学及血管内皮细胞生长因子、促红细胞生成素水平的影响  

Effects of carotid artery revascularization on the retrobulbar hemodynamics and serum VEGF and EPO levels in patients with ocular ischemic syndrome

作　　者：尹素芳 张强[1] 王海波[1] 申向辉[1] 王辉[1] 孟艳枝 侯晓英[1] YIN Sufang;ZHANG Qiang;WANG Haibo;SHEN Xianghui;WANG Hui;MENG Yanzhi;HOU Xiaoying(Department of Ultrasound Medicine,Handan Central Hospital,Handan,Hebei 056001,China)

机构地区：[1]邯郸市中心医院超声医学科,河北邯郸056001

出　　处：《安徽医药》2021年第11期2273-2276,共4页Anhui Medical and Pharmaceutical Journal

基　　金：河北省卫生和计划生育委员会资助项目(20171136)。

摘　　要：目的研究颈动脉血管重建术对眼缺血综合征病人球后血管血流动力学及血清血管内皮细胞生长因子(VEGF)、促红细胞生成素(EPO)水平的影响。方法选取2017年11月至2018年11月邯郸市中心医院收治的32例眼缺血综合征病人进行研究,采用随机数字表法将其分为对照组与观察组,各16例。对照组采用眼科保守治疗;观察组病人在眼科保守治疗的同时接受颈动脉支架形成术(CAS)治疗,比较治疗前、治疗后1周及治疗后6个月两组病人的眼动脉及视网膜中央动脉的收缩期血流峰值流速(PSV)、舒张末期血流速度(EDV)及阻力指数(RI);比较治疗前及治疗6个月后两组病人的血清VEGF、EPO、白细胞介素-6(IL-6)水平、眼压和最佳矫正视力。结果与治疗前相比,治疗后1周,两组病人的PSV、EDV水平升高,RI水平降低,治疗后6个月两组病人的血清VEGF、IL-6及眼压水平降低、最佳矫正视力升高(P<0.05);与治疗后1周对照组相比,治疗后1周观察组病人的PSV、EDV水平较高,RI水平较低(P<0.05);与治疗后6个月对照组[(385.78±105.62)ng/L,(22.31±4.27)ng/L,(23.58±4.12)mmHg]相比,治疗后6个月观察组病人的血清VEGF、IL-6及眼压水平[分别为(272.17±81.51)ng/L,(23.42±4.31)ng/L,(17.77±3.21)mmHg]较低(P<0.05)。结论颈动脉血管重建术可改善眼缺血综合征病人球后血管血流动力学降低血清中VEGF、而对血清中EPO水平的无影响。Objective To study the effects of carotid artery revascularization on the retrobulbar hemodynamics and the levels of serum vascular endothelial growth factor(VEGF)and erythropoietin(EPO)in patients with ocular ischemic syndrome.Methods A total of 32 pa‐tients with ocular ischemic syndrome treated in Handan Central Hospital from November 2017 to November 2018 were enrolled in this study and assigned into control group and observation group,with 16 cases in each group.The control group was treated with ophthalmic conservative therapy,and the observation group was treated with carotid angioplasty and stenting(CAS)in addition to ophthalmic conser‐vative treatment.The peak systolic velocity(PSV),end diastolic velocity(EDV)and resistance index(RI)of the ophthalmic artery and the central retinal artery were compared before treatment,1 week and 6 months after treatment;the levels of serum vascular endothelial growth factor(VEGF),erythropoietin(EPO),interleukin-6(IL-6),and the intraocular pressure,the best corrected visual acuity were compared be‐tween the two groups before and 6 months after treatment.Results Compared with those before treatment,the levels of PSV and EDV in the two groups increased at one week after treatment,and RI level decreased,the levels of VEGF,IL-6 and intraocular pressure in the two groups at 6 months after treatment decreased,and the best corrected visual acuity increased(P<0.05).Compared with the control group at one week after treatment,the PSV and EDV levels in the observation group were higher,and RI level was lower(P<0.05).Compared with the control group 6 months after treatment[(385.78±105.62)ng/L,(22.31±4.27)ng/L and(23.58±4.12)mmHg,respectively],the levels of serum VEGF,IL-6 and intraocular pressure in the observation group 6 months after treatment[(272.17±81.51)ng/L,(23.42±4.31)ng/L and(17.77±3.21)mmHg,respectively]were lower(P<0.05).Conclusion Carotid artery revascularization can improve the retrobulbar hemo‐dynamics of patients with ocular ischemia syndrome to decrease V

关 键 词：颈动脉狭窄 血管成形术 颈动脉血管重建术 眼缺血综合征 球后血管血流动力学 血管内皮细胞生长因子 促红细胞生成素 

分 类 号：R77[医药卫生—眼科] R654.4[医药卫生—临床医学]