肌萎缩侧索硬化运动神经元兴奋性研究进展  

The effect of exercise and motor neuron excitability on amyotrophic lateral sclerosis

作　　者：刘明生[1] 崔丽英[1] LIU MingSheng;CUI LiYing(Department of Neurology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院&北京协和医学院,北京协和医院神经科,北京100730

出　　处：《中国科学：生命科学》2021年第8期908-911,共4页Scientia Sinica(Vitae)

摘　　要：肌萎缩侧索硬化(amyotrophic lateral sclerosis, ALS)是一种累及上下云神经元的神经系统变性病,兴奋性氨基酸毒性是其发病机制之一. ALS上下运动神经元存在兴奋性异常,在不同阶段,这种兴奋性异常有所不同,本文对上下运动神经元兴奋性异常在细胞水平离子通道的变化以及ALS患者临床电生理所见的兴奋性异常的研究进展进行了综述.Amyotrophic lateral sclerosis(ALS) is a neurodegenerative disorder characterized by motor neuron loss. Excitatory amino acid toxicity and abnormal excitability of motor neurons are one of the pathogenesis of ALS. In this article, we review research progress on the dynamic changes in upper and lower motor neuron excitability at the ion channel level and their clinical neurophysiological features.

关 键 词：肌萎缩侧索硬化 上运动神经元 下运动神经元 兴奋性 

分 类 号：R744.8[医药卫生—神经病学与精神病学]