氯雷他定联合糠酸莫米松治疗变应性鼻炎的临床疗效观察  

Curative effect of loratadine combined with mometasone furoate in the treatment of allergic rhinitis

作　　者：任娟娟[1] 倪茂美[1] 汪希珂[2] REN Juanjuan;NI Maomei;WANG Xike(Otorhinolaryngology Head and Neck Surgery,Guizhou Provincial People's Hospital,Guiyang 550002,Guizhou,China;Department of Pediatrics,Guizhou Provincial People's Hospital,Guiyang 550002,Guizhou,China)

机构地区：[1]贵州省人民医院耳鼻咽喉头颈外科,贵州贵阳550002 [2]贵州省人民医院儿科,贵州贵阳550002

出　　处：《贵州医科大学学报》2021年第10期1195-1199,共5页Journal of Guizhou Medical University

基　　金：贵州省高千层次创新人才培养。

摘　　要：目的探讨氯雷他定联合糠酸莫米松对变应性鼻炎患者的治疗效果。方法将120例变应性鼻炎患者均分为对照组和观察组,对照组患者采用氯雷他定治疗,观察组患者给予氯雷他定联合糠酸莫米松治疗,均治疗4个疗程(7 d为1个疗程);比较2组患者的临床疗效与副反应,2组患者治疗前、治疗2周及4周时的鼻炎症状(TNSS)评分、临床体征评分,比较2组患者停药3个月后的复发率。结果治疗4个疗程后观察组临床治疗效果(91.7%)优于对照组(70.0%)、差异有统计学意义(P<0.05),2组患者副反应比较、差异无统计学意义(P>0.05);治疗前,2组患者TNSS评分、临床体征评分比较,差异无统计学意义(P>0.05);治疗2周及4周时,2组患者TNSS评分、临床体征评分均较治疗前降低,差异有统计学意义(P<0.05);且治疗2周及4周时观察组患者TNSS评分、临床体征评分低于对照组,差异有统计学意义(P<0.05);停药3个月随访时,观察组患者症状复发率(21.82%)低于对照组(47.62%),差异有统计学意义(χ2=7.1712,P<0.05)。结论氯雷他定联合糠酸莫米松治疗变应性鼻炎患者疗效优于单一氯雷他定治疗,复发率低。Objective To investigate the curative efficacy of loratadine combined with mometasone furoate in patients with perennial allergic rhinitis.Methods One hundred and twenty patients with allergic rhinitis were randomly divided into control group(n=60)and observation group(n=60).The control group was treated with loratadine alone.The observation group was treated with loratadine combined with mometasone furoate.After four course of treatment(1 course=7 d),the curative effects,side effects,TNSS scores of both groups before treatment,2 weeks and 4 weeks after treatment,clinical signs were compared,as well as short-term recurrence rate after medication discontinuation for 3 months.Results After 4 courses of treatment,the clinical curative effects of the observation group(91.7%)were obviously better than that of the control group(70.0%),differences were statistically significant(P<0.05);the comparison of side effects of both groups showed no statistical significance(P<0.05).Before treatment,TNSS scores of both groups,scores of clinical signs of both groups showed no statistical significance(P<0.05);2 weeks and 4 weeks after treatment,the TNSS scores of both groups,scores of clinical signs of both groups were lower than that of before treatment,differences showed statistical significance(P<0.05);2 weeks and 4 weeks after treatment,the TNSS scores and scores of clinical signs of observation groups were lower than that of control group,differences were statistically significant(P<0.05).Follow-up visit after 3 months medication discontinuation observed that recurrence rate of observation group(21.82%)was obviously lower than that of control group(47.62%),differences were statistically significant(χ2=7.1712,P<0.05).Conclusion Compared with loratadine alone,the efficacy of mometasone furoate combined with loratadine in the treatment of patients with allergic rhinitis is more significant,and the symptoms are not easy to relapse after treatment.

关 键 词：变应性鼻炎 氯雷他定 糠酸莫米松 联合治疗 临床疗效 鼻炎症状评分 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]