PTEN suppresses tumorigenesis by directly dephosphorylating Akt  

作　　者：Lang Bu Huan Wang Ji-an Pan Lang Chen Fan Xing Junyu Wu Shun Li Deyin Guo 

机构地区：[1]Institute of Precision Medicine,the First Affiliated Hospital,School of Medicine,Sun Yat-sen University,Guangzhou,Guangdong,China [2]Department of Immunology,School of Basic Medical Sciences,Wuhan University,Wuhan,Hubei,China [3]Modern Virology Research Center,College of Life Sciences,Wuhan University,Wuhan,Hubei,China [4]Present address:Institute of Synthetic Biology,Institutes of Advanced Technologies,Shenzhen,Guangdong,China

出　　处：《Signal Transduction and Targeted Therapy》2021年第8期2294-2296,共3页信号转导与靶向治疗（英文）

基　　金：This work is supported by the National Natural Science Foundation of China(#81620108020);Guangdong Zhujiang Talents Program,Shenzhen Science and Technology Program(#KQTD20180411143323605);National Ten-thousand Talents Program(all to D.G.).

摘　　要：Dear Editor,The serine-threonine kinase Akt plays a central role in regulating cell proliferation,migration,angiogenesis,transformation,energy metabolism,and death.1 The stimulation of growth factors recruits the PI3K to the plasma membrane and phosphatidylinositol-3A5-trisphosphate(PIP3),which in turn recruits Akt to the plasma membrane through PH domain of Akt.

关 键 词：METABOLISM STIMULATION DEATH 

分 类 号：R730.2[医药卫生—肿瘤]