Distinct chemokines selectively induce HIV-1 gp120-integrinα4β7 binding via triggering conformer-specific activation ofα4β7  

作　　者：Shu Wang ChangDong Lin Yue Li ZhaoYuan Liu JunLei Wang YouHua Zhang ZhanJun Yan YueBin Zhang GuoHui Li JianFeng Chen 

机构地区：[1]State Key Laboratory of Cell Biology,Center for Excellence in Molecular Cell Science,Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Shanghai 200031,China [2]Deportment of Orthopedics,Suzhou Ninth People's Hospital,Soochow University,Suzhou 215000,China [3]State Key Laboratory of Molecular Reaction Dynamics,Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023,China [4]School of Life Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou 310024,China

出　　处：《Signal Transduction and Targeted Therapy》2021年第8期2303-2306,共4页信号转导与靶向治疗（英文）

基　　金：This work was supported by grants from National Key Research and Development Program of China(2020YFA0509100);National Natural Science Foundation of China(31830112,32030024,31525016 to J.F.C,31970702,31701219 to C.D.L.);Program of Shanghai Academic Research Leader Research Program of the Chinese Academy of Sciences(XDA12010101);the Youth Innovation Promotion Association of the Chinese Academy of Sciences(2020266);the Young Elite Scientist Sponsorship Program by CAST(2019QNRC001);National Ten Thousand Talents Program.The authors gratefully acknowledge the support of SA-SIBS scholarship program.We thank Prof.Brian Seed and Dr.Slim Sassi(Massachusetts General Hospital,Boston,USA)for providing the codon optimized MN gp120 plasmid.We thank Prof.Lu Lu and Master Miao Cao(Fudan University,Shanghai,China)for providing the plasmids expressing BG505 SOSIP.664,Furin,and PGT145 for the expression and purification of BG505 SOSIP.664 gp140 trimers.(19XD1404200);Personalized Medicines-Molecular Signature-based Drug Discovery and Development,the Strategic Priority。

摘　　要：Dear Editor,Gut associated lymphoid tissue(GALT)is the principal site where human immunodeficiency virus 1(HIV-1)replicates.CD4^(+) T cells residing in GALT are predominant targets of HIV-1 during the acute phase of infection.CD4^(+) T cells expressing a high level of gut-homing receptor integrin α4β7 are more susceptible to productive infection by HIV-1.

关 键 词：α4β7 acute GP120 

分 类 号：R512.91[医药卫生—内科学]