DHODH tangoing with GPX4 on the ferroptotic stage  

作　　者：Fudi Wang Junxia Min 

机构地区：[1]The First Affiliated Hospital,The Second Affiliated Hospital,Hengyang Medical School,University of South China,Hengyang,China [2]The First Affiliated Hospital,Institute of Translational Medicine,Cancer Center,School of Public Health,Zhejiang University School of Medicine,Hangzhou,China

出　　处：《Signal Transduction and Targeted Therapy》2021年第7期1948-1949,共2页信号转导与靶向治疗（英文）

基　　金：This work was supported by research grants from the National Natural Science Foundation of China(31930057 to F.W.and 31970689 to J.M.).

摘　　要：Ferroptosis,an iron-dependent form of regulated cell death,is prevented by activity of the glutathione-dependent phospholipid hydroperoxidase GPX4(Glutathione peroxidase 4)in the cytosol and mitochondria,and by the glutathione-independent CoQ10 oxidoreductase FSP1 at the plasma membrane.In their recent paper published in Nature,Mao et al.report that DHODH(Dihydroorotate dehydrogenase)coordinates with GPX4 to block ferroptosis in the mitochondrial inner membrane by reducing ubiquinone to form ubiquinol in cancer cells,thus providing a novel targeted strategy for treating cancer.

关 键 词：CoQ10 DEATH ODH 

分 类 号：R730.5[医药卫生—肿瘤]