Chaetocin:a review of its anticancer potential and mechanisms  

作　　者：JIANG Hang-yu LI Yu-qi XIANG Xiao-cong TANG Zhi-li LIU Kang SU Qiang ZHANG Xiao-fen LI Lin 

机构地区：[1]Department of Pharmacy,The Second Clinical Medical College of North Sichuan Medical College,Nanchong 637000,China [2]School of Pharmacy,North Sichuan Medical College,Nanchong 637100,China [3]Institute of Tissue Engineering and Stem Cells,The Second Clinical Medical College of North Sichuan Medical College,Nanchong 637000,China [4]Department of Urology,The Second Clinical Medical College of North Sichuan Medical College,Nanchong 637000,China [5]College of Bioengineering,Chongqing University,Chongqing 400016,China

出　　处：《中国药理学与毒理学杂志》2021年第10期731-731,共1页Chinese Journal of Pharmacology and Toxicology

摘　　要：Chaetocin is a natural metabolite product with various biological activities and pharmacological functions isolated from Chaetomium species fungi belonging to the thiodiketopyrazines.Numerous studies have demonstrated a wide range of antitumor activities of chaetocin in vitro and in vivo.Several studies have demonstrated that chaetocin suppresses the growth and proliferation of various tumour cells by regulating multiple signalling pathways related to tumour initiation and progression,inducing cancer cell apoptosis(intrinsic and extrinsic),enhancing autophagy,inducing cell cycle arrest,as well as inhibiting tumour angiogenesis,invasion and migration.The antitumor effects and molecular mechanisms of chaetocin are reviewed and analysed in this paper,and the prospective applications of chaetocin in cancer prevention and therapy are also discussed.Our review provides the theoretical basis for exploiting the clinical application of chaetocin in cancer treatment.

关 键 词：chaetocin ANTITUMOR APOPTOSIS signalling pathway 

分 类 号：R285[医药卫生—中药学]